Table 3. . Characteristics of the ten patients with prediagnostic symptomatic interval >3 years.
| Patient number | PSI in months | Sex | Age at diagnosis (years) | Tumor location | Histopathology | Initial diagnosis | Symptoms at onset | Number of physicians consulted prior to diagnosis† | Neurologic deficits upon neurologic subspecialist consultation |
|---|---|---|---|---|---|---|---|---|---|
| 066 | 38.6 | F | 10 | Sellar-suprasellar | Cranio-pharyngioma | No data | Secondary ammenorhea, headache | 2 | Bitemporal hemianopsia, decreased visual acuity, exotropia of the left eye |
| 095 | 36.5 | F | 9 | Cerebrum (left temporal) | Ganglioglioma | Epilepsy | Seizure | 2 | Slowed speech, slow to respond, fair attention |
| 114 | 48.9 | M | 13 | Pineal | Mixed malignant GCT | Error of refraction | Blurring of vision, poor school performance | 6 | Nonreactive pupils, bilateral papilledema, parinaud syndrome |
| 124 | 60.5 | M | 14 | Sellar-suprasellar | Pituitary adenoma | Primary headache | Headache | 3 | Left temporal hemianopsia, impaired visual acuity, ilateral lateral rectus palsy |
| 127 | 38.1 | M | 4 | Sellar-suprasellar | Pilocytic astrocytoma | Error of refraction | Blurring of vision, headache | 2 | Left homonymous hemianopsia, left extremity drift, left lower extremity clonus, nystagmus |
| 137 | 48.7 | F | 13 | Cerebrum (right frontoparietal) | Ganglioglioma | No data | Left extremity numbness and weakness | 2 | Lethargy, bilateral pailledema, left central facial palsy, left hemiplegia |
| 146 | 49 | M | 11 | Cerebrum (left frontal) | Glioblastoma | No data | Headache, seizure | 2 | Right lateral rectus palsy, fair gutturals, left hemiparesis, nystagmus |
| 167 | 45.7 | F | 18 | Cerebrum (right temporal) | Ganglioglioma | Anxiety disorder | Behavioral changes (fear and panic) | 4 | No deficits, (+) seizures |
| 176 | 48.7 | F | 18 | Sellar-suprasellar | Germinoma | Unspecified gynecologic dysfunction | Secondary amenorrhea, polydipsia, polyuria | 4 | Light perception on left, right temporal hemianopsia, optic atrophy |
| 191 | 49.3 | M | 13 | Posterior fossa | Pilocytic astrocytoma | No data | Headache, vomiting | 2 | Gait ataxia, dysmetria |
Symptoms/signs are listed in the order reported or observed.
†
Number of physicians consulted prior to diagnosis excludes neurologic subspecialty consults.
F: Female; GCT: Germ cell tumor; M: Male; PSI: Prediagnostic symptomatic interval.