Table 4. . Presenting symptoms at onset, during first physician consult, and upon subspecialist consult.
| Median PSI (days) | p-value | Number of patients (percentage) presenting with the symptom | Frequency increase in number of patients presenting with the symptom from onset to subspecialist referral | ||||
|---|---|---|---|---|---|---|---|
| Patients with the symptom | Patients without the symptom | At onset | During first consult | Upon subspecialist consult | |||
| Headache | 84 | 78 | 0.620 | 115 (58.7) | 131 (66.8) | 137 (69.9) | 23 |
| Vomiting | 61 | 102 | 0.015 | 76 (38.8) | 94 (47.9) | 103 (52.6) | 27 |
| Gait imbalance/unsteady gait | 61 | 88 | 0.132 | 37 (18.9) | 61 (31.1) | 77 (39.2) | 40 |
| Blurring of vision | 92 | 77 | 0.119 | 27 (13.8) | 43 (22.4) | 61 (31.1) | 34 |
| Dizziness | 75 | 83 | 0.961 | 25 (12.8) | 31 (15.8) | 33 (16.8) | 8 |
| Diplopia | 76.5 | 83.5 | 0.918 | 16 (8.2) | 27 (13.8) | 40 (20.4) | 24 |
| Seizure | 336 | 76 | 0.021 | 10 (5.1) | 21 (10.7) | 28 (14.3) | 18 |
| Paresis | 62 | 86 | 0.312 | 9 (4.6) | 22 (11.2) | 37 (18.9) | 28 |
| Increased sleeping time | 61.5 | 85 | 0.192 | 8 (4.1) | 18 (9.2) | 30 (15.3) | 22 |
| Ocular motility dysfunction | 68 | 86 | 0.530 | 7 (3.6) | 14 (7.1) | 38 (19.4) | 31 |
| Poor school performance† | 792 | 77.5 | 0.030 | 8 (4.6) | 8 (4.6) | 8 (4.6) | 2 |
| Behavioral changes | 540 | 77.5 | 0.018 | 5 (2.6) | 5 (2.6) | 5 (2.6) | 0 |
| Secondary amenorrhea† | 365 | 77 | 0.037 | 5 (13.9) | 5 (13.9) | 5 (13.9) | 0 |
| Polydipsia/polyuria | 67 | 83 | 0.408 | 5 (2.6) | 5 (2.6) | 5 (2.6) | 0 |
| Hearing loss | 92 | 78 | 0.559 | 3 (1.5) | 7 (3.6) | 11 (5.6) | 8 |
| Numbness | 91 | 78 | 0.708 | 3 (1.5) | 3 (1.5) | 5 (2.6) | 2 |
| Facial palsy | 63 | 83 | 3 (1.5) | 7 (3.6) | 17 (8.7) | 14 | |
| Torticollis | 63 | 83 | 0.082 | 3 (1.5) | 6 (3.1) | 7 (3.6) | 4 |
†
Patients analyzed for these symptoms included only the population at risk. For poor school performance, patients aged 4 years and above (n = 175) were included, based on average age of school entry at 4 years old. For secondary amenorrhea, only females 13 years and above (n = 36) were included, based on average age of menarche for Filipino female of 13 years old.
PSI: Prediagnostic symptomatic interval.