Table 1. . Literature review.
| Study (year) | Gender | Age (years) | Imaging/level if available | Lymph nodes association | Treatment | Response or survival at the end of treatment | Ref. |
|---|---|---|---|---|---|---|---|
| Lyding et al. (1987) | Female | 32 | Intraspinal tumor/C6–C7 | Yes | 45 Gy of mantle field irradiation/5 cycles of MOPP | CR at the end of treatment | [6] |
| Higgins et al. (1995) | Male | 46 | Intraspinal, extradural, extra medullary tumor/ C5–T8 | No | Laminectomy, 8 cycles of MOPP-ABV, 30 Gy irradiation | CR at 21 months | [7] |
| Jardin et al. (1999) | Female | 36 | Intraspinal tumor/ C8–T1 | No | Intrathecal chemotherapy | Death at 2 months | [8] |
| Riffaud et al. (2003) | Male | 14 | Lumbar spinal lesion | Yes | Surgery, 6 cycles of AVD like chemotherapy/21 Gy of mantle field irradiation | CR at 1 year of the end of treatment | [9] |
| Heran et al. (2006) | Male | 42 | Lower cervical spinal mass | No | Surgical biopsy, ABVD (number of cycles not provided) | CR at the end of treatment | [10] |
| Kilani et al. (2006) | Male | 32 | Transverse myelitis T6–T7 | Yes | None | Early death | [11] |
| Al Khayat et al. (2007) | Female | 42 | Para spinal mass/C7–T1 | No | Cervical surgical biopsy, 4 cycles of ABVD and 30 Gy irradiation | CR at 12 months | [12] |
| Samadian et al. (2009) | Male | 12 | Epidural mass/L1–L3 | No | Laminectomy, 6 cycles ABVD, 24 Gy irradiation | CR and alive at 7 years | [13] |
| Chotai et al. (2010) | Male | 24 | Caudal mass/L5–S3 | No | Laminectomy/3 cycles of ABVD (treatment interrupted by the patient) | PR at 12 months | [14] |
| Yaman et al. (2013) | Male | 30 | Epidural tumor/T9–T11 | No | Laminectomy, 6 cycles of ABVD | CR at 24 months | [15] |
| Martinez et al. (2014) | Female | 74 | Lumbar intramedullary 1.4 cm mass and an enhancing lesion at the pontomedullary junction and involving the left middle and inferior cerebellar peduncle | No | Lumbar surgical biopsy, cerebral and lumbar 36 Gy irradiation | CR at 6 months | [16] |
| Williamson et al. (2020) | Female | 48 | Two spinal lesions regarding L1–L2 and L5–S1 | No | Laminectomy, 36 Gy irradiation | CR at 10 months | [17] |
| Bloxham et al. (2021) | Female | 15 | Epidural mass regarding L3, L4 and L5 | Yes | Surgical decompression/2 cycles of OEPA, 4 cycles of COPDAC and irradiation (dose not provided) | PR before irradiation | [18] |
ABVD: Doxorubicin, bleomycin, vinblastine, dacabazine; COPDAC: Cyclophosphamide, vincristine, prednisone, dacarbazine; CR: Complete response; MOPP: Mechloretamine, vincristine, procarbazine, prednisone; OEPA: Vincristine, etoposide, prednisone, doxorubicin; PR: Partial response.