TABLE 1.

Cox proportional hazard models including relevant factors and their association with incident cancer (n=437) in 4447 patients treated with continuous positive airway pressure (CPAP) for obstructive sleep apnoea over a median follow-up of 7.2 years

	Unadjusted HR (95% CI)	p-value	Adjusted# HR (95% CI)	p-value
Age, years (1sd)	1.75 (1.58–1.94)	<0.0001	1.66 (1.48–1.87)	<0.0001
Body mass index, kg·m−2 (1sd)	1.01 (0.92–1.11)	0.8391	–	–
Epworth Sleepiness Score (1sd)	0.75 (0.68–0.83)	<0.0001	0.85 (0.76–0.94)	0.0019
Male versus female gender	1.07 (0.87–1.32)	0.5007	–	–
Daily alcohol intake (yes versus no)	1.26 (1.04–1.53)	0.0181	1.05 (0.85–1.30)	0.6459
Smoking habits
Never	Ref.	–	Ref.	–
Current	0.90 (0.68–1.18)	0.0375	1.30 (0.95–1.77)	0.0974
Former	1.35 (1.09–1.66)	0.0213	1.22 (0.97–1.54)	0.0943
Prevalent diseases
Diabetes (yes versus no)	1.59 (1.28–1.97)	<0.0001	1.26 (0.98–1.63)	0.0698
Hypertension (yes versus no)	1.29 (1.07–1.56)	0.0079	0.88 (0.70–1.10)	0.2479
CVD (yes versus no)	1.37 (1.09–1.72)	0.0072	0.85 (0.65–1.11)	0.2347
COPD (yes versus no)	1.52 (1.14–2.01)	0.0037	1.11 (0.81–1.51)	0.5252
PSG (versus HSAT)	0.83 (0.68–1.01)	0.0667	1.04 (0.82–1.32)	0.7374
ln oxygen desaturation index	1.13 (0.99–1.28)	0.0520	–	–
ln apnoea-hypopnoea index	1.09 (0.99–1.19)	0.0888	–	–
ln T90	1.20 (1.08–1.34)	0.0010	0.97 (0.86–1.09)	0.6101
CPAP daily usage, h (1sd)	1.16 (1.04–1.29)	0.0097	1.07 (0.96–1.20)	0.2194
PR devices (versus non-PR devices)	0.94 (0.77–1.14)	0.5437	0.91 (0.74–1.12)	0.3835
Years of follow-up (1sd)	1.01 (0.88–1.15)	0.9405	–	–

HR: hazard ratio; CVD: cardiovascular diseases; HSAT: type 3 home sleep apnoea testing; PSG: polysomnography; T90: % of sleep (recording) time with oxygen saturation <90%; PR: Philips Respironics. ^#: adjusted for variables with a p-value below 0.15 in the univariate Cox model and for a competing risk of death.