Figure 1.

OSE Inhibits proliferation of a battery of breast cancer cell lines (MDA-MB 231 (A), MDAMB-453 (B), MDAMB-134 (C) T47-D (D), without significantly inducing cytotoxicity in normal human mammary epithelial cells (MCF10A) (E). Cells were treated with increasing concentrations of OSE (0.8, 1.2 and 1.6 mg/ml) for 24, 48, and 72 h Cell viability was assessed by the overall metabolic activity measured by MTT. Values are calculated as % of the corresponding vehicle control value and represented as mean ± standard error of the mean (SEM) of three independent experiments, each run in triplicate. (*p < 0.05, **p < 0.01 and ***p < 0.005).