Table 2.
Meta-analysis of high CD68+ TAMs density and clinicopathological features of breast cancer patients.
| Clinicopathological features | References | No. of studies | Model | Pooled OR (95% CI) | P value | Heterogeneity | |
|---|---|---|---|---|---|---|---|
| I2 (%) | P value | ||||||
| Tumor nest | |||||||
| Age (< 50 y vs ≥ 50 y) |
≥ 50 years | 9 | Random | 0.59 (0.33-1.04) | 0.07 | 93 | < 0.001 |
| Tumor size (< 2cm vs ≥ 2cm) |
≥ 2cm | 9 | Random | 0.36 (0.15-0.85) | 0.02 | 96 | < 0.001 |
| Lymph node status (N0 vs. N1-3) |
N1-3 | 7 | Random | 0.74 (0.13-1.29) | 0.28 | 90 | < 0.001 |
| Histological grade (І, II vs III) |
III | 13 | Random | 0.85 (0.46-1.56) | 0.60 | 95 | < 0.001 |
| Vascular invasion (yes vs no) |
No | 3 | Random | 0.40 (0.28-0.58) | < 0.001 | 55 | 0.11 |
| Ki-67 status (positive vs negative) |
Negative | 4 | Random | 4.23 (1.33-13.48) | 0.01 | 94 | < 0.001 |
| ER status (positive vs negative) |
Negative | 9 | Random | 2.23 (1.19-4.18) | 0.01 | 94 | < 0.001 |
| PR status (positive vs negative) |
Negative | 7 | Random | 1.34 (0.88-2.04) | 0.17 | 78 | < 0.001 |
| HER-2 status (positive vs negative) |
Negative | 8 | Random | 0.08 (0.05-0.14) | < 0.001 | 88 | < 0.001 |
| Tumor stroma | |||||||
| Age (< 50 y vs ≥ 50 y) |
≥ 50 years | 5 | Random | 0.48 (0.13-1.85) | 0.29 | 96 | < 0.001 |
| Tumor size (< 2cm vs ≥ 2cm) |
≥ 2cm | 5 | Random | 0.59 (0.12-2.94) | 0.52 | 97 | < 0.001 |
| Lymph node status (N0 vs. N1-3) |
N1-3 | 3 | Random | 0.71 (0.21-2.42) | 0.59 | 91 | < 0.001 |
| Histological grade (І, II vs III) |
III | 5 | Random | 0.32 (0.08-1.35) | 0.12 | 97 | < 0.001 |
| Vascular invasion (yes vs no) |
No | 2 | Random | 0.08 (0.01-2.16) | 0.13 | 94 | < 0.001 |
| Ki-67 status (positive vs negative) |
Negative | 1 | – | 0.32 (0.21-0.49) | – | – | – |
| ER status (positive vs negative) |
Negative | 3 | Random | 5.00 (3.68-6.80) | < 0.001 | 94 | < 0.001 |
| PR status (positive vs negative) |
Negative | 3 | Random | 1.23 (0.60-2.55) | 0.57 | 80 | 0.006 |
| HER-2 status (positive vs negative) |
Negative | 3 | Random | 0.21 (0.01-6.81) | 0.38 | 99 | < 0.001 |
TAMs, tumor-associated macrophages; OR, odds ratio; CI, confidence interval; ER, oestrogen receptor; PR, progesterone receptor; HER-2, human epidermal growth factor receptor-2.