Table 3.
Meta-analysis of high CD163+ TAMs density and clinicopathological features of breast cancer patients.
| Clinicopathological features | References | No. of studies | Model | Pooled OR(95% CI) | P value | Heterogeneity | |
|---|---|---|---|---|---|---|---|
| I2 (%) | P value | ||||||
| Tumor nest | |||||||
| Age (< 50 y vs ≥ 50 y) |
≥ 50 years | 4 | Random | 0.21 (0.13-0.34) | < 0.001 | 65 | 0.04 |
| Tumor size (< 2cm vs ≥ 2cm) |
≥ 2cm | 5 | Random | 0.34 (0.12-1.00) | 0.05 | 95 | < 0.001 |
| Lymph node status (N0 vs. N1-3) |
N1-3 | 3 | Random | 0.94 (0.21-4.13) | 0.93 | 95 | < 0.001 |
| Histological grade (І, II vs III) |
III | 5 | Random | 0.41 (0.13-1.31) | 0.13 | 95 | < 0.001 |
| Vascular invasion (yes vs no) |
No | 2 | Fixed | 0.56 (0.38-0.82) | 0.003 | 17 | 0.27 |
| Ki-67 status (positive vs negative) |
Negative | 2 | Random | 4.70 (0.88-25.00) | 0.07 | 93 | < 0.001 |
| ER status (positive vs negative) |
Negative | 2 | Fixed | 3.55 (2.58-4.88) | < 0.001 | 51 | 0.15 |
| PR status (positive vs negative) |
Negative | 1 | – | 1.81 (0.92-3.57) | 0.09 | – | – |
| HER-2 status (positive vs negative) |
Negative | 2 | Random | 0.11 (0.01-0.79) | 0.03 | 94 | < 0.001 |
| Tumor stroma | |||||||
| Age (< 50 y vs ≥ 50 y) |
≥ 50 years | 4 | Random | 1.71 (0.57-5.08) | 0.34 | 90 | < 0.001 |
| Tumor size (< 2cm vs ≥ 2cm) |
≥ 2cm | 5 | Random | 0.31 (0.06-1.54) | 0.15 | 96 | < 0.001 |
| Lymph node status (N0 vs. N1-3) |
N1-3 | 4 | Random | 1.98 (0.44-8.96) | 0.38 | 95 | < 0.001 |
| Histological grade (І, II vs III) |
III | 5 | Random | 0.36 (0.06-2.19) | 0.27 | 97 | < 0.001 |
| Vascular invasion (yes vs no) |
No | 1 | – | 0.03 (0.01-0.09) | – | – | – |
| Ki-67 status (positive vs negative) |
Negative | 1 | – | 2.52 (1.30-4.85) | – | – | – |
| ER status (positive vs negative) |
Negative | 2 | Random | 2.96 (0.61-14.35) | 0.18 | 91 | 0.001 |
| PR status (positive vs negative) |
Negative | 3 | Fixed | 1.22 (0.87-1.71) | 0.26 | 46 | 0.16 |
| HER-2 status (positive vs negative) |
Negative | 3 | Random | 0.25 (0.02-2.53) | 0.24 | 97 | < 0.001 |
TAMs, tumor-associated macrophages; OR, odds ratio; CI, confidence interval; ER, oestrogen receptor; PR, progesterone receptor; HER-2, human epidermal growth factor receptor-2.