Table 1.
- Characteristics of septic patients who received antibiotics within one hour versus those who received antibiotics between one and 3 hours.
| Characteristics | Overall N=292 | Within 1 hour n=250 | Between 1 and 3 hours n=42 | P-value |
|---|---|---|---|---|
| Mean age, years (±SD) | 56.3 (23.6) | 55.3 (23.8) | 61.2 (22.2) | 0.1754 |
| SBP <90 mmHg | 65 (22.3) | 58 (23.2) | 7 (16.7) | 0.9804 |
| Vasopressor use | 39 (13.4) | 34 (13.6) | 5 (11.9) | 0.0893 |
| Laboratory | ||||
| Creatinine, mean (±SD) | 186.1 (224.1) | 193.0 (233.8) | 144.8 (148.5) | 0.1593 |
| First lactate value, mmol/L, mean (±SD) | 3.4 (2.7) | 3.5 (2.7) | 3.0 (2.5) | 0.2937 |
| Leucocytosis (WBC >11) or leukopenia (<4) | 161 (55.1) | 142 (56.8) | 19 (45.2) | 0.1633 |
| Hospital mortality | 93 (31.8) | 79 (31.6) | 14 (33.3) | 0.8230 |
| Any comorbidities | 145 (49.6) | 123 (49.2) | 22 (52.4) | 0.7028 |
| Diabetes mellitus | 87 (29.8) | 86 (34.4) | 1 (2.4) | <0.0001 |
| Hypertension | 101 (34.6) | 99 (39.6) | 2 (4.8) | <0.0001 |
| Congestive heart failure | 12 (4.1) | 7 (2.8) | 5 (11.0) | 0.0059 |
| Kidney failure | 21 (7.2) | 19 (7.6) | 2 (4.8) | 0.5100 |
| Oncology | 19 (6.5) | 14 (5.6) | 5 (11.9) | 0.1253 |
| Source of infection | ||||
| Pneumonia empyema | 108 (37.0) | 106 (42.4) | 2 (4.8) | <0.0001 |
| Urinary tract infection | 29 (9.9) | 23 (9.2) | 6 (14.3) | 0.3079 |
| Acute abdominal infection | 8 (2.7) | 7 (2.8) | 1(2.4) | 0.8776 |
| Meningitis | 14 (4.8) | 8 (3.2) | 6 (14.3) | 0.0019 |
| Skin/soft tissue infection | 32 (11) | 26 (10.4) | 6 (14.3) | 0.4557 |
| Bone/joint infection | 7 (2.4) | 1 (0.4) | 6 (14.3) | <0.0001 |
| Wound infection | 7 (2.4) | 1 (0.4) | 6 (14.3) | <0.0001 |
| Blood stream catheter infection | 7 (2.4) | 1 (0.4) | 6 (14.3) | <0.0001 |
Values are presented as number and percentages (%). WBC: white blood cells, SBP: systolic blood pressure, SD: standard deviation