Table 2.
- The genotype frequencies of the Dombrock blood group polymorphism c.793A>G (rs11276) in Western Saudi Arabians compared with African and East Asian populations listed in the 1000 Genomes database.
| Western Saudis/1000 genomes populations | DO genotype frequency (n) | P-value† | Post-hoc | ||||
|---|---|---|---|---|---|---|---|
| DO*01/01 | DO*01/02 | DO*02/02 | DO*01/01 vs. non - DO*01/01 | DO*01/02 vs. non - DO*01/02 | DO*02/02 vs. non - DO*02/02 | ||
| % (n) | P-value‡ (df=1) | ||||||
| Western Saudis | 0.18 (80) | 0.5 (220) | 0.32 (140) | - | - | - | - |
| Africans | 0.06 (43) | 0.41 (269) | 0.53 (349) | <0.001 | <0.001 | 0.002 | <0.001 |
| ACB | 0.07 (7) | 0.4 (38) | 0.53 (51) | <0.001 | 0.009 | 0.064 | <0.001 |
| ASW | 0.1 (6) | 0.42 (26) | 0.47 (29) | 0.035 | 0.105 | 0.28 | 0.020 |
| ESN | 0.06 (6) | 0.38 (38) | 0.56 (55) | <0.001 | 0.003 | 0.037 | <0.001 |
| GWD | 0.02 (2) | 0.42 (48) | 0.56 (63) | <0.001 | <0.001 | 0.154 | <0.001 |
| LWK | 0.09 (9) | 0.36 (36) | 0.54 (54) | <0.001 | 0.028 | 0.014 | <0.001 |
| MSL | 0.09 (8) | 0.46 (39) | 0.45 (38) | 0.030 | 0.542 | 0.487 | 0.022 |
| YRI | 0.05 (5) | 0.41 (44) | 0.55 (59) | <0.001 | <0.001 | 0.084 | <0.001 |
| East Asians | 0.01 (6) | 0.17 (87) | 0.81 (411) | <0.001 | <0.001 | <0.001 | <0.001 |
| CDX | 0.02 (2) | 0.16 (15) | 0.82 (76) | <0.001 | 0.004 | <0.001 | <0.001 |
| CHB | 0.02 (2) | 0.17 (18) | 0.81 (83) | <0.001 | <0.001 | <0.001 | <0.001 |
| CHS | 0 (0) | 0.18 (19) | 0.82 (86) | <0.001 | <0.001 | <0.001 | <0.001 |
| JPT | 0.01 (1) | 0.19 (20) | 0.8 (83) | <0.001 | <0.001 | <0.001 | <0.001 |
| KHV | 0.01 (1) | 0.15 (15) | 0.84 (83) | <0.001 | <0.001 | <0.001 | <0.001 |
DO: Dombrock, ACB: African Caribbeans in Barbados, ASW: Americans of African ancestry in southwestren United States, ESN: Esan in Nigeria, GWD: Gambian in western divisions in the Gambia, LWK: Luhya in Webuye, Kenya, MSL: Mende in Sierra Leone, YRI: Yoruba in Ibadan, Nigeria, CDX: Chinese Dai in Xishuangbanna, China, CHB: Han Chinese in Beijing, China, CHS: Southern Han Chinese, JPT: Japanese in Tokyo, Japan, KHV: Kinh in Ho Chi Minh City, Vietnam, †calculated Chi-squared p-value using 3×2 contingency tables. A p-value of ≤0.05 was considered significant and can be further analyzed using post-hoc analyses with Bonferroni correction, ‡type I error was corrected by dividing the desired α=0.05 over the number of tests (0.05/3=0.0167), a p-value of ≤0.0167 was considered significant for post-hoc analyses