Table 3.
- The genotype frequencies of the Dombrock blood group polymorphism c.793A>G (rs11276) in Western Saudi Arabians compared with those in American, European, and South Asian populations listed in the 1000 Genomes database.
| Western Saudis/1000 genomes populations* | DO genotype frequency (n) | P-value† | Post-hoc | ||||
|---|---|---|---|---|---|---|---|
| DO*01/01 | DO*01/02 | DO*02/02 | DO*01/01 vs. non - DO*01/01 | DO*01/02 vs. non - DO*01/02 | DO*02/02 vs. non - DO*02/02 | ||
| % (n) | P-value‡ (df=1) | ||||||
| Western Saudis | 0.18 (80) | 0.5 (220) | 0.32 (140) | - | - | - | - |
| Americans | 0.14 (49) | 0.47 (162) | 0.39 (136) | 0.067 | - | - | - |
| CLM | 0.15 (14) | 0.44 (41) | 0.41 (39) | 0.194 | - | - | - |
| MXL | 0.12 (8) | 0.50 (32) | 0.37 (24) | 0.452 | - | - | - |
| PEL | 0.09 (8) | 0.43 (37) | 0.47 (40) | 0.013 | 0.048 | 0.275 | 0.007 |
| PUR | 0.18 (19) | 0.50 (52) | 0.32 (33) | 1.000 | - | - | - |
| Europeans | 0.14 (70) | 0.47 (235) | 0.39 (198) | 0.031 | 0.016 | 0.290 | 0.053 |
| CEU | 0.11 (11) | 0.48 (48) | 0.40 (40) | 0.122 | - | - | - |
| FIN | 0.08 (8) | 0.38 (38) | 0.53 (53) | <0.001 | <0.001 | 0.179 | <0.001 |
| GBR | 0.14 (13) | 0.50 (46) | 0.35 (32) | 0.632 | - | - | - |
| IBS | 0.17 (18) | 0.49 (53) | 0.34 (36) | 0.913 | - | - | - |
| TSI | 0.19 (20) | 0.47 (50) | 0.35 (37) | 0.818 | - | - | - |
| South Asians | 0.13 (64) | 0.51 (249) | 0.36 (176) | 0.078 | - | - | - |
| BEB | 0.12 (10) | 0.52 (45) | 0.36 (31) | 0.32 | - | - | - |
| GIH | 0.13 (13) | 0.41 (42) | 0.47 (48) | 0.016 | 0.178 | 0.092 | 0.005 |
| ITU | 0.2 (20) | 0.51 (52) | 0.29 (30) | 0.878 | - | - | - |
| PJL | 0.09 (9) | 0.55 (53) | 0.35 (34) | 0.110 | - | - | - |
| STU | 0.12 (12) | 0.56 (57) | 0.32 (33) | 0.276 | - | - | - |
DO: Dombrock, CLM: Colombians from Medellin, Colombia, MXL: Mexican ancestry from Los Angeles, United States, PEL: Peruvians from Lima, Peru, PUR: Puerto Ricans from Puerto Rico, CEU: Utah residents (CEPH) with Northern and Western European ancestry, FIN: Finnish in Finland, GBR: British in England and Scotland, IBS: Iberian population in Spain, TSI: Toscani in Italy, BEB: Bengali from Bangladesh, GIH: Gujarati Indian from Houston, Texas, ITU: Indian Telugu from the United Kingdom, PJL: Punjabi from Lahore, Pakistan, STU: Sri Lankan Tamil from the United Kingdom, †calculated Chi-squared p-value using 3×2 contingency tables. A p-value of ≤0.05 was considered significant and can be further analyzed using post-hoc analyses with Bonferroni correction, ‡type I error was corrected by dividing the desired α=0.05 over the number of tests (0.05/3=0.0167), a p-value of ≤0.0167 was considered significant for post-hoc analyses