PICOTS component	Details
Participants	Patients with COVID-19 suspected symptoms or asymptomatic population screening
Interventions	Saliva specimens RT-qPCR results of detect SARS-CoV-2
Comparisons	Naso/oropharyngeal specimens RT-qPCR results of detect SARS-CoV-2
Outcomes	Diagnostic accuracy, specificities, and negative predictive values analysis
Timings	From inception to August 2021
Study design	A systematic review and meta-analysis

COVID-19: coronavirus disease-19, RT-qPCR: reverse transcription quantitative polymerase chain reaction, SARS-CoV-2: severe acute respiratory syndrome coronavirus-2