Table 2. Prevalence of Components of H2FPEF and HFA-PEFF Scores.
| Score component | No. (%) | P value | |
|---|---|---|---|
| Control individuals (n = 173) | Patients with HFpEF (n = 563) | ||
| H2FPEF score | |||
| Age >60 y | 97 (56) | 461 (82) | <.001 |
| Obesitya | 50 (29) | 335 (59) | <.001 |
| Treated with ≥2 antihypertensives | 64 (37) | 375 (67) | <.001 |
| Any AF | 14 (8) | 212 (38) | <.001 |
| E/e′>9 | 66 (39) | 381 (71) | <.001 |
| PASP>35 mm Hg | 25 (17) | 249 (49) | <.001 |
| HFA-PEFF score | |||
| Functional domain | |||
| Septal e′<7 (age <75 y) or <5 (age >75 y) | 45 (27) | 187 (35) | .05 |
| Septal e′<7 | 58 (34) | 258 (48) | .002 |
| E/e′≥15 | 16 (10) | 152 (28) | <.001 |
| TR velocity >2.8 | 15 (13) | 171 (40) | <.001 |
| E/e′ of 9-14 | 50 (30) | 221 (41) | .006 |
| Functional domain scoreb | |||
| 2 | 63 (36) | 373 (66) | <.001 |
| 1 | 19 (11) | 80 (14) | |
| 0 | 91 (53) | 110 (20) | |
| Morphological domain | |||
| LAVI>34 (sinus) or >40 (AF) | 58 (36) | 237 (48) | .008 |
| LAVI of 29-34 (sinus) or 34-40 (AF) | 34 (21) | 90 (18) | .42 |
| RWT>0.42 and LVMI≥149 (male) or ≥122 (female) | 2 (1) | 17 (3) | .27 |
| RWT>0.42 | 45 (26) | 233 (43) | <.001 |
| LV wall thickness ≥12 | 18 (11) | 151 (28) | <.001 |
| LVMI≥115 (male) or ≥95 (female) | 21 (13) | 113 (21) | .01 |
| Morphological domain scorec | |||
| 2 | 60 (35) | 243 (43) | .003 |
| 1 | 49 (28) | 198 (35) | |
| 0 | 64 (37) | 118 (21) | |
| Natriuretic peptide domain | |||
| NTproBNP level >220 (sinus) or >660 (AF)d | 31 (24) | 243 (52) | <.001 |
| NTproBNP level of 125-220 (sinus) or 375-660 (AF)e | 24 (18) | 75 (16) | .54 |
| Natriuretic peptide scoref | |||
| 2 | 31 (24) | 243 (52) | <.001 |
| 1 | 24 (18) | 75 (16) | |
| 0 | 76 (58) | 148 (32) | |
Abbreviations: AF, atrial fibrillation; e′, septal mitral annulus tissue relaxation velocity in early diastole; E/e′, ratio of early diastolic mitral inflow velocity to e′; HFpEF, heart failure with preserved ejection fraction; LAVI, left atrial volume index; LV, left ventricle; LVMI, LV mass index; NTproBNP, N-terminal pro brain natriuretic peptide; PASP, pulmonary artery systolic pressure; RWT, relative wall thickness; TR, tricuspid regurgitation.
Defined as a body mass index greater than 30 (calculated as weight in kilograms divided by height in meters squared).
Scores range from 0 to 2, with higher scores indicating higher functional domain score component of HFA-PEFF score.
Scores range from 0 to 2, with higher scores indicating higher morphological domain score component of HFA-PEFF score.
Includes 37 patients with BNP measurements from 1 center who had BNP greater than 80 (sinus) or greater than 240 (AF).
Includes 37 patients with BNP measurements from 1 center who had BNP of 35 to 80 (sinus) or 105 to 240 (AF).
Scores range from 0 to 2, with higher scores indicating higher natriuretic peptide domain score component of HFA-PEFF score.