Table 3. Operating Characteristics of Individual Score Components in Isolation.
| Score component | OR (95% CI) | AUC (95% CI) | Sensitivity | Specificity | P value |
|---|---|---|---|---|---|
| H2FPEF score | |||||
| Age >60 y | 3.55 (2.45-5.13) | 0.629 (0.589-0.669) | 82 | 44 | <.001 |
| Obesitya | 3.60 (2.49-5.21) | 0.652 (0.614-0.693) | 59 | 71 | <.001 |
| ≥2 Antihypertensives | 3.38 (2.37-4.82) | 0.648 (0.606-0.688) | 67 | 63 | <.001 |
| Any AF | 6.84 (3.86-12.12) | 0.648 (0.619-0.676) | 38 | 92 | <.001 |
| E/e′>9 | 3.91 (2.72-5.62) | 0.662 (0.621-0.704) | 72 | 61 | <.001 |
| PASP>35 mm Hg | 4.69 (2.95-7.46) | 0.660 (0.622-0.697) | 49 | 83 | <.001 |
| HFA-PEFF score | |||||
| Functional domain | |||||
| Septal e′<7 (age <75 y) or <5 (age >75 y) | 1.47 (1.00-2.16) | 0.541 (0.502-0.580) | 35 | 73 | .048 |
| Septal e′<7 | 1.77 (1.23-2.53) | 0.568 (0.527-0.610) | 48 | 66 | .002 |
| E/e′>15 | 3.82 (2.21-6.60) | 0.595 (0.566-0.625) | 29 | 90 | <.001 |
| TR velocity >2.8 m/s | 4.53 (2.54-8.05) | 0.637 (0.598-0.676) | 40 | 87 | <.001 |
| E/e′>9 | 3.91 (2.72-5.62) | 0.662 (0.621-0.704) | 72 | 61 | <.001 |
| Functional domain score | 4.88 (3.30-7.21) | 0.676 (0.634-0.720) | NA | NA | <.001 |
| Morphological domain | |||||
| LAVI>34 mL/m2 (SR) or >40 mL/m2 (AF) | 1.65 (1.14-2.38) | 0.561 (0.517-0.604) | 48 | 64 | .008 |
| LAVI>29 mL/m2 (SR) or >34 mL/m2 (AF) | 0.83 (0.54-1.30) | 0.514 (0.478-0.551) | NA | NA | .42 |
| RWT>0.42 g/m2 and LVMI≥149 (male) or ≥122 g/m2 (female) | 2.75 (0.63-12.0) | 0.510 (0.499-0.521) | NA | NA | .18 |
| RWT>0.42 | 2.11 (1.44-3.09) | 0.583 (0.544-0.623) | 43 | 74 | <.001 |
| LV wall thickness ≥12 mm | 3.23 (1.91-5.45) | 0.585 (0.556-0.615) | 28 | 89 | <.001 |
| LVMI≥115 (male) or ≥95 g/m2 (female) | 1.86 (1.12-3.07) | 0.542 (0.512-0.573) | 21 | 87 | .02 |
| Morphological domain score | 1.47 (1.19-1.82) | 0.580 (0.532-0.627) | 79 | 37 | <.001 |
| Natriuretic peptide domain | |||||
| NTproBNP level >220 (SR) or >660 (AF)b | 3.52 (2.26-5.47) | 0.642 (0.600-0.685) | 52 | 76 | <.001 |
| NTproBNP level >125 (SR) or >375 (AF)c | 0.86 (0.52-1.42) | 0.511 (0.474-0.548) | NA | NA | .55 |
| Natriuretic peptide score | 1.98 (1.58-2.49) | 0.660 (0.612-0.708) | NA | NA | <.001 |
Abbreviations: AF, atrial fibrillation; AUC, area under the curve; e′, septal mitral annulus tissue relaxation velocity in early diastole; E/e′, ratio of early diastolic mitral inflow velocity to e′; LAVI, left atrial volume index; LV, left ventricle; LVMI, LV mass index; NA, not applicable; NTproBNP, N-terminal pro brain natriuretic peptide; OR, odds ratio; PASP, pulmonary artery systolic pressure; RWT, relative wall thickness; SR, sinus rhythm; TR, tricuspid regurgitation.
Defined as a body mass index greater than 30 (calculated as weight in kilograms divided by height in meters squared).
Includes 37 patients with BNP measurements from 1 center who had BNP greater than 80 (sinus) or greater than 240 (AF).
Includes 37 patients with BNP measurements from 1 center who had BNP of 35 to 80 (sinus) or 105 to 240 (AF).