Figure 7.
Evaluation of toxicity of Sodium Houttuyfonate combined with Matrine in rats. Ulcerative colitis models were established with mucous membranes of colons sensitized with TNBS-alcohol enteroclysis. Treatments were administered with SASP, Sodium Houttuyfonate combined with Matrine. (A) Body weight changes. (B) Hepatorenal function changes. ALT, AST, BUN, and Cr were evaluated. (C) HE staining of liver and kidney. (D) Fecal characteristics. TNBS, immune- 2,4,6-trinitrobenzene sulfonic acid; SASP, sulfasalazine; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; Cr, Creatinine. and Compared with the model group, #P < 0.05.