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. 2022 Jun 30;12:909111. doi: 10.3389/fcimb.2022.909111

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Copyright © 2022 Kumar, Parate, Danishuddin, Zeb, Singh, Lee, Jung, Lee and Ha

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The ribbon diagram of the SYK protein showing an overlay of Hypo1 inside the active site of different SYK domains. The regions of the SYK active site such as the hinge region (448–455), glycine-rich loop (378–383), DFG motif (512–514), and the activation loop (520–534) were highlighted. (B) The mapping of Hypo1 features with SYK active site residues. The SYK residues were shown with a stick representation in different colors: hinge (cyan), G-loop (teak), DFG motif (pink), and other active site surrounding resides (gray).