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. 2022 Jun 30;13:908478. doi: 10.3389/fimmu.2022.908478

Figure 3.

Figure 3

The influence of homologous and heterologous booster immunization programs on serum neutralization titers and breadth. (A) Mice booster immunization schedule. The original RBD-WT mRNA vaccine group was divided into two (n = 4 mice per group): group I (the RBD-WT+WT+WT mRNA group) mice were boosted with the RBD-WT mRNA vaccine, and group II (the RBD-WT+WT+O mRNA group) mice with the RBD-O mRNA vaccine. The original RBD-O mRNA vaccine group (re-named the RBD-O+O+O mRNA group) received a third dose of the RBD-O mRNA vaccine. Serum samples were collected at week 8. (B) Neutralizing titers of the week-4 and week-8 antisera samples from each group against WT-, Delta-, and Omicron-PV (pseudovirus). If serum samples show less than 50% neutralization at the 1:200 dilution, a NT50 value of 100 was assigned for statistical analysis. ns, not significant; *p < 0.05; **p < 0.01. (C) Neutralizing titers of the week-8 antisera from the three vaccine groups against SARS-CoV-2 PVs. The geometric mean of NT50 values was shown.