Table 1.
Overview of several signaling pathways associated with the repolarization of tumor-associated macrophages.
| Author | Disease | Year | Molecule | Mechanism | Function | References |
|---|---|---|---|---|---|---|
| Huffaker, T B et al. | melanoma | 2021 | IFNγ, NAMPT | Activate JAK/STAT1 signaling pathway | M1 polarization and better melanoma outcome | (35) |
| Kang Le et al. | Mantle cell lymphoma | 2021 | IL-10 | Activate JAK/STAT1 signaling pathway | promote mantle cell lymphoma growth | (36) |
| Wenli Fang et al. | Breast cancer | 2021 | Progranulin | Activate JAK/STAT3 signaling pathway | M2 polarization and up-regulated the PD-L1 expression of TAMs |
(32) |
| Qian Zhong et al. | Colorectal cancer | 2020 | CPEB3 | Inhibit IL-6R/JAK/STAT3 signaling pathway | Attenuated tumor occurrence and inhibited CD163+ TAM polarization | (37) |
| Sifeng Tao et al. | Breast cancer | 2020 | linc00514 | Activate STAT3/Jagged1/Notch signaling pathway | M2 polarization and breast cancer metastasis | (38) |
| Tao Yu et al. | / | 2019 | Trim24 | STAT6 K383 acetylation | Restrain macrophage M2 polarization | (39) |
| Ying Wang et al. | Esophageal squamous cell carcinoma | 2020 | FOXO1 | Activate FAK/PI3K/AKT signaling pathway | M2 polarization | (40) |
| Jason K. Sa et al. | Glioblastoma | 2020 | MARCO | Activate PI3Kγ/AKT signaling pathway, PTEN loss | M2 polarization and promote tumor growth | (41) |
| Man Li et al. | Pancreatic cancer | 2020 | BEZ | Inhibit PI3K/AKT signaling pathway | M1 polarization | (42) |
| Zhu et al. | Diffuse large B-cell lymphoma | 2019 | NSE | Enhance nuclear p50 translocation and inhibit NF-κB signaling pathway | M2 polarization and promotie the progression of lymphoma | (43) |
| Chia-Sing Lu | Non-small cell lung cancer | 2020 | JSH-23 | Inhibit NF-κB signaling pathway | Restrain macrophage M2 polarization | (44) |
| Zhenxing Wang et al. | Non-small cell lung cancer | 2020 | CtBP1 | Activate NF-κB signaling pathway | CCL2 secretion and M2 polarization | (45) |
| Marta Di Martile et al. | Melanoma | 2020 | Bcl-2 | Activate NF-κB signaling pathway | Activation of IL-1β and M2 polarization | (46) |
| Michael Zhang et al. | Glioblastoma | 2016 | Anti-CD47 antibody | Inhibit CD47-SIRPα signaling pathway | M1 polarization | (47) |
NAMPT, the rate limiting enzyme in NAD salvage synthesis; CPEB3, Cytoplasmic polyadenylation element binding protein 3; Trim24, a CBP-associated E3 ligase; FOXO1, The transcription factor forkhead box protein O1; MARCO, the macrophage receptor with collagenous structure; BEZ, PI3k-γ inhibitor; NSE, neuron-specific enolase.