TABLE 2.
Clinical trials for osteochondral defects.
| S. No. | Title | Condition | Scaffold used | No. of participants | Study start date | Expected end date | Country | Status |
|---|---|---|---|---|---|---|---|---|
| 1 | Repair of Articular Osteochondral Defect | Osteochondritis dissecans | Biphasic osteochondral composite | 10 | March 2009 | December 2011 | Taiwan | Unknown status |
| 2 | A Study to Evaluate the Efficacy of BioCartilage® Micronized Cartilage Matrix in Microfracture Treatment of Osteochondral Defects | Osteochondral defect | BioCartilage® micronized cartilage matrix | 15 | January 2019 | November 2023 | Canada | Recruiting |
| 3 | Follow-up Study Evaluating the Long-Term Outcome of ChondroMimetic in the Treatment of Osteochondral Defects in the Knee | Osteochondral defect | ChondroMimetic | 15 | May 2017 | February 2018 | Hungary | Completed |
| 4 | A Prospective, Post-Marketing Registry on the Use of ChondroMimetic for the Repair of Osteochondral Defects | Osteochondral defects | Chondromimetic | 8 | September 2010 | April 2013 | Hungary | Terminated |
| 5 | A Study to Evaluate the Safety of Augment™ Bone Graft | Defect of articular cartilage | Augment Bone Graft | 1 | July 2011 | August 2012 | Canada | Completed |
| 6 | Transplantation of Bone Marrow Stem Cells Stimulated by Protein Scaffolds to Heal Defects in Articular Cartilage of the Knee | Osteoarthritis|knee Osteoarthritis|osteochondritis | Transplantation of bone marrow stem cells | 50 | July 2010 | December 2014 | France | Unknown status |
| 7 | The Effectiveness of Adding Allogenic Stem Cells After Traditional Treatment of Osteochondral Lesions of the Talus (OLT) | Osteochondral fracture of talus | Allogenic stromal mesenchymal cells derived from the umbilical cord | platelet-poor plasma Scaffold | 70 | 15 January 2019 | December 2024 | Chile | Recruiting |
| 8 | One-Step Bone Marrow Mononuclear Cell Transplantation in Talar Osteochondral lesions | Osteochondritis | Procedure: bone marrow cells transplantation on collagen scaffold | 140 | April 2013 | April 2018 | Italy | Unknown |
| 9 | Study for the Treatment of Knee Chondral and Osteochondral Lesions | Knee chondral lesion knee osteochondral lesion |
Procedure: Marrow stimulation—drilling or microfractures device: MaioRegen surgery | 145 | January 2011 | February 2016 | Europe and South Africa | Completed |
| 10 | Triphasic Osteochondral Scaffold for the Treatment of the OCD of the Knee: Observational Study | Osteochondritis dissecans knee | Triphasic Scaffold | 30 | 1 April 2022 | April 2029 | Italy | Recruiting |
| 11 | Evaluation of an Acellular Osteochondral Graft for Cartilage Lesions Pilot Trial (EAGLE Pilot) | Articular cartilage injury | Device: Kensey Nash Corp. Cartilage repair device | 2 | June 2010 | May 2014 | United States | Terminated |
| 12 | Biphasic Cartilage Repair Implant (BiCRI) IDE Clinical Trial-Taiwan | Chondral or osteochondral lesion of medial femoral condyle chondral or osteochondral lesion of lateral femoral condyle chondral or osteochondral lesion of trochlea | Device: Biphasic cartilage repair implant | 92 | October 2011 | August 2019 | Taiwan | Completed |