Table 1.
Changes of Th cell subsets or their signature cytokine levels in mental disorders.
| Mental disorders | Depressive disorder | Schizophrenia | Autism spectrum disorders |
|---|---|---|---|
| Th cell subsets | |||
| Th1 (IFN-γ) | ↑ (313) | ↓ (317) | ↑ (336, 344) |
| ↓ (304, 308) | |||
| - (361) | |||
| Th2 (IL-4) | ↓ (302) | ↑ (317, 328) | ↑ (336, 344) |
| ↑ (303, 304) | |||
| - (305–307) | |||
| Th1/Th2 ratio | ↑ (301, 306, 362) | ↓ (317) | ↓ (335, 336) |
| ↓ (304) | |||
| Treg (TGF-β, IL-10) | ↓ (295, 309, 312) | ↓ (318–320) | ↓ (337, 344) |
| ↑ (311) | ↑ (321) | ||
| Th17 (IL-17) | ↑ (303, 312–314) | ↑ (324–327) | ↑ (337, 339–341, 344) |
| ↓ (315, 316) | ↓ (328, 329) |
↑, upregulation; ↓, downregulation; -, no significant change.