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. Author manuscript; available in PMC: 2022 Jul 14.
Published in final edited form as: Adv Healthc Mater. 2021 Mar 18;10(9):e2001941. doi: 10.1002/adhm.202001941

Figure 4.

Figure 4.

Oxidation-responsive BMP-2 release from PTK-BAA films in vitro. (A) Conventional PBAE films primarily release their BMP-2 payload in a bolus over the first 24h regardless of 1 mM H2O2 treatment, while PTK-BAA films release significantly more BMP-2 in the peroxide media compared against release in pure PBS. (B) PTK-BAA / BMP-2 film-coated samples incubated in constant doses of 1 mM H2O2 released protein consistently over time, whereas samples intermittently incubated in PBS or peroxide released significantly less protein in PBS but equivalent BMP-2 amounts when incubated in H2O2. During the later cycles, the “on-off” responsiveness behavior is delayed but still apparent. All PEM films were constructed with 30 tetralayers on PLGA scaffolds and utilized 450 kDa PAA as the polyanion (n=3 per treatment, *p<0.05).