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. Author manuscript; available in PMC: 2022 Jul 14.
Published in final edited form as: Adv Healthc Mater. 2021 Mar 18;10(9):e2001941. doi: 10.1002/adhm.202001941

Figure 7.

Figure 7.

In vivo bone regeneration in critically-sized rat calvarial defects from oxidation-sensitive, BMP-2-coated implants. BMP-2 / PTK-BAA LbL films (30 tetralayers) with varying PAA polyanion molecular weights (450, 5, or 1.8 kDa) were constructed on PLGA scaffolds and implanted into 8 mm diameter rat calvarial bone defects for 4 weeks. (A) Non-invasive microcomputed tomography images of the calvarial bone were collected at week 4 post-surgery (original defect margins in red, new bone growth tinted blue, scale bar 5 mm, n=4 animals per group). Quantitation of (B) bone volume and (C) tissue mineral density inside the defect margins demonstrated that the PAA1.8 films facilitated significantly more bone growth and mineralization than higher molecular weight PAA films (*p<0.05), corresponding to the PAA1.8 samples’ increased BMP-2 release rates following oxidation.