Figure 8.

In vivo BMP-2 release from ROS-sensitive PTK-BAA and conventional PBAE-coated implants in rat calvarial defects. As quantified from (A) fluorescence imaging of Cy7-labeled BMP-2, growth factor delivery from the PTK-coated scaffolds (B) exhibits a lower initial bolus discharge and is significantly extended compared against PBAE films. Importantly though, over 95% of the PTK film’s drug payload is released over a three-week time course. (C) Quantification of half-life values for the respective release profiles (displayed as a 95% confidence interval) further demonstrates a nearly three-fold increase in drug retention for PTK-BAA coatings. N=3 animals per treatment, *p<0.05.