Table 3.
Reproductive outcomes per embryo transfer.
| Characteristic | NC | HRT | GnRH-a+HRT (n = 846) | P | |
|---|---|---|---|---|---|
| (n = 4306) | (n = 1007) | ||||
| Clinical pregnancy rate | 2103/4306 (48.8%) | 483/1007 (48.0%) | 399/846 (47.1%) | 0.633 | |
| Implantation rate | 2464/6051 (40.7%) | 549/1400 (39.2%) | 461/1213 (38.0%) | 0.162 | |
| Heterotopic | 28/2103 | 10/483 | 5/399 | 0.444 | |
| pregnancy | -1.33% | -2.30% | -1.25% | ||
| Twins and multiple pregnancies | 312/4306 (7.25%) | 52/1007 | 33/846* | <0.001 | |
| -5.16% | -3.90% | ||||
| Miscarriage rates(1st or 2nd trimester) | 481/2103 (22.9%) | 132/483 (27.3%) | 90/399 | 0.101 | |
| -22.60% | |||||
| 1st | 394/2103 (18.7%) | 117/483 (24.2%)* | 74/399 | 0.021 | |
| trimester | -18.50% | ||||
| 2nd trimester | 87/2103 | 15/483 | 16/399 | 0.576 | |
| -4.14% | -3.11% | -4.01% | |||
| Miscarriage rate of singleton pregnancies | 428/2103 (20.4%) | 123/483 (25.5%)* | 79/399 | 0.036 | |
| -19.80% | |||||
| Miscarriage rate of multiple pregnancies | 53/2103 | 9/483 | 11/399 | 0.632 | |
| -2.52% | -1.86% | -2.76% | |||
| Stillbirths | 2/2103 (0.0951%) | 0 | 1/399 | 0.5 | |
| -0.25% | |||||
| Live birth rate | 1595/4306 (37.0%) | 343/1007 (34.1%) | 302/846 (35.7%) | 0.19 | |
| Singletons | 1402/4306 (32.6%) | 307/1007 (30.5%) | 269/846 | 0.437 | |
| -31.80% | |||||
| Twins | 193/4306 (4.48%) | 36/1007 (3.57%) | 33/846 | 0.377 | |
| -3.90% | |||||
| Preterm births | 214/2103 (10.2%) | 57/483 | 36/399 | 0.383 | |
| -11.80% | -9.02% | ||||
*Compared to the NC, P < 0.05; # = compared to the HRT cycle, P < 0.05; NC, natural cycle; HRT, hormone replacement therapy; GnRH-a, gonadotropin-releasing hormone agonist.