Table 2.
ICU patient clinical characteristics for flow cytometric analysis of CD15 blood counts.
| Sepsis (n = 20) | SIRS (n = 14) | |
|---|---|---|
| Demographics | ||
| Age mean (SD) (years) | 69.1 (13.2) | 64.4 (12.9) |
| Male/female | 10/10 | 11/3 |
| Infections [n (%)] a | ||
| Gram-negative bacteria | 4 (20) | |
| Gram-positive bacteria | 1 (5) | |
| Fungal | 1 (5) | |
| Viral | 0 (0) | |
| Treatments [n (%)] | ||
| Anti-infective b | 18 (90) | 0 (0)**** |
| Mechanical ventilation | 19 (95) | 5 (36)**** |
| Renal replacement therapy | 2 (10) | 0 (0) |
| Catecholamines c | 19 (95) | 5 (36)*** |
| Comorbidities [n (%)] d | ||
| Renal disease | 2 (10) | 1 (7) |
| Peripheral vascular disease | 4 (20) | 4 (29) |
| Congestive heart failure | 8 (40) | 2 (14) |
| Any malignancy e | 4 (20) | 5 (36) |
| Metastatic solid tumor | 1 (5) | 0 (0) |
| Plegiaf | 1 (5) | 0 (0) |
| Diabetes with chronic complications | 2 (10) | 0 (0) |
| Diabetes without chronic complications | 14 (70) | 3 (21)* |
| Mild liver disease | 1 (5) | 1 (7) |
| Dementia | 0 (0) | 0 (0) |
| Chronic pulmonary disease | 3 (15) | 1 (7) |
| Myocardial infarction | 2 (10) | 0 (0) |
| Cerebrovascular disease | 0 (0) | 0 (0) |
| Hospital mortality [n (%)] | 8 (40) | 2 (14) |
| SOFA score (SD) g,h | 9.8 (2.2) | 6.5 (3.3)** |
| Blood parameters [mean (SD)] | ||
| CRP (mg/L) h | 242.2 (117.2) | 82.4 (51.8)**** |
| Lactate (mmol/L)g,i | 2.55 (1.84) | 1.72 (1.20) |
| Sodium (mmol/L) j | 141.5 (4.7) | 137.7 (2.6)** |
| Total bilirubin k (mg/dl) | 0.92 (0.67) | 1.23 (1.14) |
| Creatinine (mg/dl) | 1.55 (0.65) | 1.39 (0.76) |
| Platelets (109/L) | 243.3 (141.1) | 209.7 (96.2) |
| CRP (mg/L) g | 242.2 (117.2) | 82.4 (51.8)**** |
| White blood cells (109/L) l | 14.34 (5.98) | 15.55 (9.23) |
| Septic focus m | ||
| Pulmonary | 10 | |
| Abdominal | 7 | |
| Soft tissue | 2 | |
| SIRS etiology | ||
| Abdominal surgeryn,o | 9 | |
| Vascular surgeryo,p | 4 | |
| Polytrauma | 2 | |
SD, standard deviation.
Microbiology laboratory-confirmed infections.
This term indicates antibacterial, antimycotic, or antiviral drugs or combined treatment.
This term denotes adrenalin, noradrenalin, dobutamine, or combined treatment.
In accordance with the charted Charlson Comorbidity Index.
This term includes leukemia and lymphoma.
Hemiplegia or paraplegia.
SOFA score and CRP and lactate levels were determined on ICU admission.
For four SIRS patients, complete data to derive the SOFA score were not available.
For five patients with SIRS, lactate determinations were not available.
For two SIRS patients, sodium determinations were not available.
For two patients with sepsis and one with SIRS, determinations of total bilirubin were not available.
For one sepsis patient, white blood cell counts were not available.
The septic focus remained unclear in one patient.
Includes cystectomy and esophagectomy.
°One patient had combined abdominal and vascular surgery.
Includes aortic surgery.
****p < 0.0001; ***p < 0.001; **p < 0.01; *p < 0.05 after Mann–Whitney U test or Fisher’s exact test for sepsis vs. SIRS.