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. 2022 Jun 30;13:929716. doi: 10.3389/fgene.2022.929716

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Copyright © 2022 Ren, Tian, Meng and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model of AMX-1 in sterility compared with SPR-5. AMX-1 and SPR-5 function in both redundant and non-redundant manners. In wild-type animals, both AMX-1 and SPR-5 are necessary for proper fertility and sterility and maintenance of H3K4me2 level. While spr-5 sterility does not require p53/CEP-1, amx-1 sterility requires p53/CEP-1. AMX-1 modulates the adequate expression of Piwis in a CEP-1-dependent manner; thus, the absence of AMX-1 expression results in sterility. AMX-1 and SPR-5 are necessary for ICLR and DSBR, respectively.