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. 2022 Jun 27;94(27):9530–9539. doi: 10.1021/acs.analchem.1c03564

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© 2022 The Authors. Published by American Chemical Society

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Dissecting multiple mechanisms of NI01 into substructure derivatives and corresponding modes of action. (A) Three 2-helix substructures derived from NI01. (B) Schematics representing the inner and outer leaflets of a single lipid bilayer and the corresponding mechanisms of membrane thinning or transmembrane lesions for each of the substructures. The schematic is based on the interpreted data from the in-liquid AFM topography images of anionic PC/PG (3:1) SLBs treated with the two-helix hairpins (AFM images shown in Figure S7). (C) Heat plots mapping the modes of action of the three substructures, α1α2, α2α3, and α3α4 against anionic PC/PG (3:1) GUVs.