Table 2.
Interactions of host genetics (metabolic and immune-related single nucleotide polymorphism) with gut bacteria
|
Ref.
|
Size
|
Analysis
|
Gene
|
SNP
|
Function
|
Bacteria
|
Ethnicity
|
Comment
|
| Knights et al[59], 2014 | 474 IBD | 16S RNA | NOD2 | rs5743293, rs104895431, rs104895467, rs2068844, rs2068845, rs5743277, rs5743293 | Innate immunity | Enterobacteriaceae | Europeans | IBD |
| Blekhman et al[122], 2015 | 93 (HMP) | Metagenomic | LCT | rs2304371, rs3754689 | Metabolism | Bifidobacterium, SMB53 (Clostridiaceae) | Multi-ethnic | NS |
| GNA12 | rs1182182 | IBD | ||||||
| Goodrich et al[123], 2016 | 1126 | Fecal 16S rRNA | CD36 | rs1360741 | Immune-related | Blautia | Europeans | United Kingdom twins |
| Li et al[137], 2016 | 10523 IBD, 5726 IBD | Mucosal 16S rRNA | SLC39A8 | rs13107325 | Immune-related | Composition | ND | IBD |
| Bonder et al[68], 2016 | 1514 | Metagenomic | C11orf30-LRRC32 | rs2155219 | IBD | Coprococcus comes/Proteobacteria | AA1 PCa risk | |
| CCL2 | rs3091315, rs3091316 | Immune-related | Methonobacteria | |||||
| DAP2 | rs267939 | Innate immunity | Bifidobacterium | |||||
| IL23R | rs12141575 | Immune-related | Enterobacteriaceae/E. coli | |||||
| IL10 | rs18008711 | Immune-related | Proteobacteria/Sutterella | |||||
| MUC22 | rs3873352 | Barrier defense | ||||||
| NOD1 | rs12669082 | Innate immunity | Enterobacteriaceae/E.coli | |||||
| rs41524946 | Innate immunity | Enteroba cteriaceae/E. coli | ||||||
| rs55689059 | Innate immunity | Enterobacteriaceae/E. coli | ||||||
| rs55841603 | Innate immunity | Enterobacteriaceae/E. coli | ||||||
| NOD2 | rs8056611, rs2357792, | Innate immunity | Enterobacteriaceae/E. coli | |||||
| CD209 | rs1010046 | Innate immunity | Bacteroidetes | |||||
| Rühlemann et al[138], 2021 | 8956 | 16S rRNA/GWAS | FUT2 | rs602662 | Barrier defense | Bacteroides OTU97_27 | Europeans | |
| BLVRA | rs623108 | Innate immunity | Barnesiella spp. OTU99_55 |
1
Studies include an analysis according to the population origins.
AA: African-American; GWAS: Genome-wide association studies; HMP: Human Microbiome Project; IBD: Inflammatory bowel disease; SNP: Single nucleotide polymorphism; ND: Not determined; NS: Not significant; PCa: Prostate cancer; rRNA: Ribosomal RNA; E. coli: Escherichia coli; FUT2: Fucosyltransferase 2; NOD2: Nucleotide binding oligomerization domain containing protein 2; LCT: Lactase; GNA12: Guanine nucleotide-binding protein alpha-12; CCL2: C-C motif chemokine ligand 2; IL: Interleukin; MUC22: Mucin 22; BLVRA: Biliverdin reductase.