Table 9.
Analysis of pathogenic mutation sites in tumor tissues
|
Gene
|
Location
|
Amino acid mutation
|
Mutation frequency
|
N
|
M
|
| TP53 | Exon 4 | R110L | 1 | ||
| Exon 5 | R175H | 4 | |||
| Y163C | 1 | ||||
| C176Y | 1 | ||||
| Exon 6 | R1961 | 2 | |||
| Y220C | 2 | ||||
| Exon 7 | R248Q/W | 3 | |||
| G245S/C | 2 | ||||
| Exon 8 | R273H/C | 4 | |||
| R282W | 2 | ||||
| R3061 | 1 | ||||
| Exon 10 | R3421 | 1 | 24/40 | 23/31 | |
| KRAS | Exon 2 | G12D/V/S | 22 | ||
| G13D/C | 4 | ||||
| Exon 3 | Q61H | 1 | 27/30 | 27/29 | |
| APC | Exon 17 | Q8861 | 1 | ||
| S1483fs | 1 | ||||
| R8761 | 2 | ||||
| R14501 | 2 | ||||
| E13061 | 1 | ||||
| Q12941 | 1 | ||||
| G13121 | 1 | 9/15 | 9/12 |
1
Indicates stop codon.
N: Pathogenic sites/total mutation sites; M: Number of pathogenic cases/total number of mutation cases.