Table 2. Fitted Parameter Values and R² for the Different Equation Models Used to Determine the Release Mechanism of the Drugs from the Films^a.

release model	Sample	pH = 7.4	pH = 5.5
zero-order (Mt = k0t)	Chi/PCL-PMMA-EUD-Dap	k0 (h–1) = 0.31	k0 (h–1) = 0.16
		R2 = 0.42	R2 = 0.15
	Chi/PCL- Dap	k0 (h–1) = 0.29	k0 (h–1) = 0.35
		R2 = 0.20	R2 = 0.76
	Chi/PCL-PMMA-Van	k0 (h–1) = 0.42	k0 (h–1) = 0.33
		R2 = 0.52	R2 = 0.39
	Chi/PCL-Van	k0 (h–1) = 0.28	k0 (h–1) = 0.39
		R2 = 0.32	R2 = 0.29
first-order (Mt = 1–e–k1t)	Chi/PCL-PMMA-EUD-Dap	k1 (h–1) = 25.1	k1 (h–1) = 21.1
		R2 = 0.77	R2 = 0.73
	Chi/PCL- Dap	k1 (h–1) = 32.6	k1 (h–1) = 22.4
		R2 = 0.77	R2 = 0.91
	Chi/PCL-PMMA-Van	k1 (h–1) = 33.1	k1 (h–1) = 27.6
		R2 = 0.98	R2 = 0.90
	Chi/PCL-Van	k1 (h–1) = 18.3	k1 (h–1) = 39.7
		R2 = 0.49	R2 = 0.89
Hixson–Crowell	Chi/PCL-PMMA-EUD-Dap	k = 0.49	k = 0.49
		R2 = 0.48	R2 = 0.15
	Chi/PCL- Dap	kHC = 1.07	kHC = 1.1
		R2 = 0.12	R2 = 0.74
	Chi/PCL-PMMA-Van	kHC = 1.00	kHC = 1.0
		R2 = 0.48	R2 = 0.39
	Chi/PCL-Van	kHC = 1.16	kHC = 1.2
		R2 = 0.32	R2 = 0.21
Higuchi (Mt = kH √t)	Chi/PCL-PMMA-EUD-Dap	kH(h–1/2) = 0.15	k(h–1/2) = 0.082
		R2 = 0.42	R2 = 0.38
	Chi/PCL- Dap	kH(h–1/2) = 0.14	kH(h–1/2) = 0.18
		R2 = 0.2	R2 = 0.74
	Chi/PCL-PMMA-Van	kH(h–1/2) = 0.21	kH(h–1/2) = 0.17
		R2 = 0.5	R2 = 0.44
	Chi/PCL-Van	kH(h–1/2) = 0.14	kH(h–1/2) = 0.19
		R2 = 0.32	R2 = 0.28
Korsemeyer–Peppas (Mt = kKPtn)	Chi/PCL-PMMA-EUD-Dap	kKP(h–1/2) = 5.29	kKP(h–1/2) = 5.98
		R2 = 0.93	R2 = 0.92
		n = 0.13	n = 0.21
	Chi/PCL- Dap	kKP(h–1/2) = 4.31	kKP(h–1/2) = 4.90
		R2 = 0.94	R2 = 0.92
		n = 0.13	n = 0.21
	Chi/PCL-PMMA-Van	kKP(h–1/2) = 3.86	kKP(h–1/2) = 5.15
		R2 = 0.91	R2 = 0.73
		n = 0.54	n = 0.24
	Chi/PCL-Van	kKP(h–1/2) = 5.58	kKP(h–1/2) = 3.45
		R2 = 0.99	R2 = 0.79
		n = 0.32	n = 1.07

^aMt denotes the fraction of drug released up to time t; k₀, k₁, k_HC, k_H, and k_KP are constants of the mathematical models; n is the release exponent of the Korsmeyer–Peppas model.