Table 2.
Prevalence and odds ratio of thyroid dysfunction in the DFBC depending on sex and famine exposure group (born before, late, mid, or early gestation, or conceived after) as well as sex in a subsample for which thyroid function tests were available (n=728).
| Timing of gestational exposure to famine | Sex | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Born before (n=209) | Late gestation exposure (n=119) | Mid gestation exposure (n=106) | Early gestation exposure (n=66) | Conceived after (n=228) | Women (n=373) | Men (n=355) | All (n=728) | |||
| Overt hypothyroidism | % (n) | 6.2 (12) | 3.4 (4) | 6.6 (7) | 3.0 (2) | 3.1 (7) | 5.9 (22) | 2.8 (10) | 4.4 (32) | |
| OR [95%CI] | 1.92 [0.76, 5.26] |
1.10 [0.28, 3.71] |
2.23 [0.74, 6.69] |
0.99 [0.14, 4.20] |
– |
2.16
[1.04, 4.84] |
– | – | ||
| Overt hyperthyroidism | % (n) | 1.4 (3) | 2.5 (3) | 2.8 (3) | 3.0 (2) | 2.6 (5) | 3.5 (13) | 0.9 (3) | 2.2 (16) | |
| OR [95%CI] | 0.65 [0.13, 2.68] |
1.15 [0.23, 4.78] |
1.30 [0.26, 5.39] |
1.39 [0.20, 6.63] |
– |
4.24
[1.35, 18.60] |
– | – | ||
| Thyroid autoantibody positivity | % (n) | 3.3 (7) | 3.4 (4) | 1.9 (2) | 1.5 (1) | 1.3 (3) | 3.7 (14) | 0.8 (3) | 2.3 (17) | |
| OR [95%CI] | 2.26 [0.72, 12.29] |
1.16 [0.06, 9.26] |
1.44 [0.19, 8.82] |
2.63 [0.57, 13.55] |
– |
4.54
[1.47, 19.81] |
– | – | ||
Bolded values indicate a p-value <0.05