Table 1.

Schedule of enrollment, interventions and assessments

	Enrollment	Pre allocation			Allocation	Post allocation				Close-out
Content	Screening and baseline assessment	Controlled ovarian hyperstimulation	Oocyte retrieval and semen preparation	ICSI and Assessment of embryo	Blastocyst culture and randomization	PGT-A and/or Embryo frozen	Embryo transfer	Evaluation of pregnancy	Follow-up of pregnancy
Time point	T0 3 months	T1 1 month	T2 0 months	T3 1–2 days	T4 5–6 days	T5 1–2 months	T6 4–5 days	T7 1 month	T8 3–10 months	T9 3 months
Enrollment
Eligibility screen	√	√	√	√	√
Informed consent	√
Allocation					√
Interventions
Conventional ICSI						√
ICSI+PGT-A						√
Assessment
Baseline data	√
Laboratory tests	√	√	√				√	√	√	√
Fertilisation				√
Embryo quality				√	√
Pregnancy tests								√
Pregnancy outcomes									√	√
Fetus information									√	√
Safety assessment		√	√				√	√	√	√

ICSI, intracytoplasmic sperm injection; PGT-A, preimplantation genetic testing for aneuploidies.