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. 2022 Jul 13;10(7):e004589. doi: 10.1136/jitc-2022-004589

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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CD47/SIRPα blockade indirectly enhances T cell responses through myeloid cells. CD47/SIRPα blockade enhances T cell responses through (upper right) the cross-priming and maturation abilities of DCs and production of T cell response promoting cytokines and chemokines, and (lower right) the cross-presentation and chemokine production of macrophages. While trogoptosis by neutrophils (lower left) and ADCC by NK cells (upper left) is promoted through CD47/SIRPα blockade, it is unknown whether this affects T cell responses directly. Figure created with BioRender.com. ADCC, antibody-mediated cellular toxicity; CD47, cluster of differentiation 47; DCs, dendritic cells; NK, natural killer; SIRPα, signal regulatory protein alpha.