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. 2022 Jul 13;10(7):e004589. doi: 10.1136/jitc-2022-004589

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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MHC-I-deficient tumors are sensitized to CD47/SIRPα blockade. The inhibitory receptor LILRB1, which binds surface MHC I, shows synergy with other inhibitory receptor pathways, including the CD47/SIRPα axis. Figure created with BioRender.com. CD47, cluster of differentiation 47; LILRB1, Leukocyte immunoglobulin-like receptor subfamily B member 1; MHC-I, major histocompatibility complex I; SIRPα, signal regulatory protein alpha.