Figure 5.

Network analysis by partial correlation identifies specific pathways associated with the resolution phase lipids. (A) Schematic for partial correlation between resolution lipids, lipid pathway transcripts and genome-wide transcripts. The n denotes the number of genes/lipids retained after the filtering process applied in partial correlation. (B) Venn diagram showing partially correlated genes with globosides (Gb3 and Gb4) and cholesteryl esters (CE). Pathway analysis on the shared 82 genes is shown on the right panel. (C) Venn diagram highlighting the most significant non-redundant pathway in globosides and CE. KEGG pathways are shown on the panel below. (D) Elsevier Pathways for Gb4 d18:1/16:0 and CE 20:4. P and P_adj denote the P-value and the adjusted P-value, respectively. (E) Network representation based on partial correlation for Gb4 d18:1/16:0 and CE 20:4. For panels (B, C), the bar chart shows the top 10 enriched terms in the chosen library, along with their corresponding p-values. Colored bars correspond to terms with significant p-values (<0.05). * next to a p-value indicates the term also has a significant adjusted p-value (<0.05).