TABLE 3.

Differential Gene Expression as a Function of Patient Age and Tear Size^a

Gene Expression in Adipogenic Medium			Gene Expression in Beige-Inducing Medium
Gene	Age β Coefficient; P Value	Tear Size β Coefficient; P Value	Gene	Age β Coefficient; P Value	Tear Size β Coefficient; P Value
Adiponectin	0.19; .11	−0.68; .7	Adiponectin	0.081; .4	−1.15; .53
PPARy	0.22; .17	36.67; .001	PPARy	0.058; .39	−1.55; .26
FABP4	0.89; .04	−4.7; .42	FABP4	0.86; .023	1.98; .65
CEBP	0.096; .48	25.58; .002	CEBP	0.1; .051	−1.49; .099
Leptin	0.04; .58	9.24; .004	Leptin	0.025; .53	0.75; .36
CD36	0.059; .53	6.45; .029	CD36	0.0018; .513	0.35; .531
UCP1	0.136; .21	9.71; .011	UCP1	5.14; .019	−1921.83; <.0001
PRDM16	1.13; .022	−33.74; .0007	PRDM16	5.1; .019	−1930.57; <.0001
MTUS1	0.24; .15	−2.48; .38	MTUS1	4.36; .026	−922.28; <.0001
EVA1	−0.41; .7	16.1; .45	EVA1	4; .039	−1145.19; <.0001
ZIC1	0.45; .018	−5.95; .048	ZIC1	0.11; .18	−7.91; .007
KCNK3	0.0057; .052	−0.083; .1	KCNK3	1.22; .54	−15.98; .13
Col1A	0.0035; .098	−0.041; .248	Col1A	0.0095; .52	0.56; .12
Col3A	0.00043; .64	0.0077; .67	Col3A	0.0056; .48	0.196; .25
ACTA2	0.012; .093	−0.25; .39	ACTA2	0.0045; .022	0.48; <.0001
F288	0.13; .078	−2.5; .074	F288	1.89; .043	−216.54; <.0001
F315	0.031; .1	−1.46; .012	F315	4.51; .024	−805.85; <.0001
IGF1	0.05; .017	−1.09; .012	IGF1	1.97; .041	−219.25; <.0001

^aBold values indicate P < .05.