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. 2022 Jun 24;7(27):23289–23301. doi: 10.1021/acsomega.2c01399

Table 1. Reaction Conditions and Yields for the Synthesis of 7a.

comp. Ar1 Ar2 time (h) yield (%)
7a 2-OH-phenyl phenyl 7 93
7b 2-OH-phenyl 2-Cl-phenyl 16 42
7c 2-OH-phenyl 3-Cl-phenyl 26 74
7d 2-OH-phenyl 4-Cl-phenyl 25 31
7e 2-OH-phenyl 2,5-(Cl)phenyl 17 37
7f 2-OH-phenyl 4-CN-phenyl 24 69
7g 2-OH-phenyl 3-Br-phenyl 19 73
7h 2-OH-phenyl 4-Br-phenyl 15 54
7i 2-OH-phenyl 3-F-phenyl 19 65
7j 2-OH-phenyl 4-tolyl 24 70
7k 2-OH-phenyl 2-OMe-phenyl 18 40
7l 2-OH-phenyl 3-NO2-phenyl 15 89
7m 2-OH-phenyl benzo[d](1,3]dioxol-5-yl 17 28
7n 2-OH-phenyl 6-OMe-naphthalen-2-yl 16 54
7o 2-OH-phenyl furan-2-yl 24 53
7p 2-OH-3-OMe-phenyl 3-NO2-phenyl 66 49
7q 2-OH-3-OMe-phenyl 2-Cl-phenyl 68 51
7r 2-OH-naphthalenyl 2-Br-phenyl 14 73
a

1.2 equiv of 11 were used except for compounds 7a (1.0 equiv), 7i (1.5 equiv), and 7j (1.5 equiv).