Table 1. Reaction Conditions and Yields for the Synthesis of 7a.
comp. | Ar1 | Ar2 | time (h) | yield (%) |
---|---|---|---|---|
7a | 2-OH-phenyl | phenyl | 7 | 93 |
7b | 2-OH-phenyl | 2-Cl-phenyl | 16 | 42 |
7c | 2-OH-phenyl | 3-Cl-phenyl | 26 | 74 |
7d | 2-OH-phenyl | 4-Cl-phenyl | 25 | 31 |
7e | 2-OH-phenyl | 2,5-(Cl)phenyl | 17 | 37 |
7f | 2-OH-phenyl | 4-CN-phenyl | 24 | 69 |
7g | 2-OH-phenyl | 3-Br-phenyl | 19 | 73 |
7h | 2-OH-phenyl | 4-Br-phenyl | 15 | 54 |
7i | 2-OH-phenyl | 3-F-phenyl | 19 | 65 |
7j | 2-OH-phenyl | 4-tolyl | 24 | 70 |
7k | 2-OH-phenyl | 2-OMe-phenyl | 18 | 40 |
7l | 2-OH-phenyl | 3-NO2-phenyl | 15 | 89 |
7m | 2-OH-phenyl | benzo[d](1,3]dioxol-5-yl | 17 | 28 |
7n | 2-OH-phenyl | 6-OMe-naphthalen-2-yl | 16 | 54 |
7o | 2-OH-phenyl | furan-2-yl | 24 | 53 |
7p | 2-OH-3-OMe-phenyl | 3-NO2-phenyl | 66 | 49 |
7q | 2-OH-3-OMe-phenyl | 2-Cl-phenyl | 68 | 51 |
7r | 2-OH-naphthalenyl | 2-Br-phenyl | 14 | 73 |
1.2 equiv of 11 were used except for compounds 7a (1.0 equiv), 7i (1.5 equiv), and 7j (1.5 equiv).