Table 7. Formulation Composition of Azithromycin In Situ Ophthalmic Gel.
batch code | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 |
---|---|---|---|---|---|---|---|---|---|
AZM:SBE-β-CD ratio | 1:1 | 1:1 | 1:1 | 1:2 | 1:2 | 1:2 | 2:1 | 2:1 | 2:1 |
AZM:SBE-β-CD (g) | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Carbopol 934P (g) | 0.4 | 0.6 | 0.8 | 0.4 | 0.6 | 0.8 | 0.4 | 0.6 | 0.8 |
HPMC K4M (g) | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 |
edetate disodium (g) | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 |
benzalkonium chloride (g) | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 |
citric acid (g) | 0.40 | 0.40 | 0.40 | 0.40 | 0.40 | 0.40 | 0.40 | 0.40 | 0.40 |
disodium hydrogen Phosphate(g) | 1.12 | 1.12 | 1.12 | 1.12 | 1.12 | 1.12 | 1.12 | 1.12 | 1.12 |
purified water (q.s.) | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |