Table 3.

Multivariate Cox regression analysis of disease-free survival in esophageal squamous cell carcinoma.

Variable	Categories	7th-edition staging, SUVmax (median cutoff)			7th-edition staging, SUVmax (best cutoff)			8th-edition staging, SUVmax (median cutoff)			8th-edition staging, SUVmax (best cutoff)
		Hazard ratio	95% confidence interval	p	Hazard ratio	95% confidence interval	p	Hazard ratio	95% confidence interval	p	Hazard ratio	95% confidence interval	p
Sex	Female vs. Male	1.989	0.970–4.082	0.061	2.043	0.995–4.194	0.052	2.110	1.030–4.322	0.041	2.153	1.050–4.412	0.036
Clinical N stage	N0
	N1	1.491	1.063–2.091	0.021	1.456	1.040–2.037	0.029	1.507	1.074–2.116	0.018	1.473	1.052–2.062	0.024
	N2	1.101	0.657–1.844	0.716	1.107	0.664–1.845	0.697	1.291	0.771–2.159	0.331	1.308	0.785–2.178	0.303
	N3	2.222	0.641–7.709	0.208	2.772	0.796–9.652	0.109	2.821	0.829–9.600	0.097	3.410	0.996–11.673	0.051
Adjuvant therapy	No
	CCRT	0.526	0.159–1.736	0.292	0.563	0.171–1.853	0.344	0.639	0.193–2.119	0.464	0.681	0.206–2.252	0.529
	RT	2.173	0.874–5.403	0.095	2.385	0.959–5.933	0.062	2.348	0.933–5.912	0.070	2.478	0.986–6.228	0.054
	CT	0.742	0.540–1.075	0.121	0.796	0.565–1.122	0.193	0.805	0.569–1.138	0.220	0.842	0.586–1.189	0.328
Histological grade	1
	2	0.775	0.488–1.231	0.280	0.748	0.471–1.187	0.217	0.737	0.475–1.142	0.172	0.719	0.464–1.113	0.139
	3	0.951	0.553–1.635	0.857	0.971	0.564–1.672	0.916	0.874	0.520–1.469	0.611	0.896	0.533–1.507	0.679
7th pathological stage	IA
	IB	1.332	0.376–4.720	0.657	1.232	0.347–4.377	0.747
	IIA	1.131	0.213–5.996	0.885	1.008	0.193–5.272	0.993
	IIB	1.648	0.452–6.013	0.449	1.387	0.381–5.054	0.620
	IIIA	4.648	1.278–16.899	0.020	4.101	1.137–14.791	0.031
	IIIB	9.063	2.472–33.230	<0.001	8.113	2.241–29.368	0.001
	IIIC	11.541	3.098–42.984	<0.001	9.376	2.539–34.623	<0.001
8th pathological stage	IA
	IB							2.730	0.363–20.511	0.329	2.147	0.283–16.272	0.460
	IIA							3.226	0.382–27.272	0.282	2.374	0.279–20.202	0.429
	IIB							3.763	0.486–29.133	0.204	2.688	0.343–21.085	0.347
	IIIA							5.602	0.692–45.356	0.106	3.972	0.487–32.422	0.198
	IIIB							12.610	1.632–97.411	0.015	9.526	1.231–73.718	0.031
	IVA							22.485	2.844–177.804	0.003	15.420	1.936–122.832	0.010
SUVmax (median cutoff)	<4.7
	≥4.7	2.196	1.426–3.381	<0.001				1.999	1.286–3.106	0.002
SUVmax (best cutoff)	<3.4
	≥3.4				3.258	1.886–5.687	<0.001				2.982	1.703–5.219	<0.001