TABLE 2.
Baseline CSF sTREM2, progranulin, p-tau, t-tau concentration, Aβ42/Aβ40 ratio, and adjusted brain volume of CN group with amyloid-negative, CN, MCI, and AD groups with amyloid-positive.
| CN A– | CN A+ | MCI A+ | AD A+ | P | |
| sTREM2 (pg/mL) | 3992.36 (2798.34) | 4291.04 (3536.94) | 3764.52 (2726.17) | 3465.27 (2306.77) | 0.42 |
| progranulin (pg/mL) | 1578.44 (525.12) | 1471.59 (459.98) | 1494.49 (422.83) | 1594.63 (439.91) | 0.26 |
| t-tau (pg/mL) | 203.7 (71.6) | 264.0 (95.6) | 314.2 (166.2) | 363.4 (148.9) | <0.001 |
| p-tau (pg/mL) | 17.67 (6.73) | 24.16 (13.07) | 31.48 (17.83) | 37.37 (16.05) | <0.001 |
| Aβ42/Aβ40 | 0.187 (0.045) | 0.102 (0.039) | 0.085 (0.035) | 0.085 (0.028) | <0.001 |
| HV (mm3) | |||||
| 1.5T | 7224.69 ± 755.54 | 7319.12 ± 770.25 | 6247.05 ± 969.86 | 5800.33 ± 1108.60 | |
| 3.0T | 7645.41 ± 862.99 | 7440.50 ± 767.24 | 6764.74 ± 1064.47 | 5898.88 ± 847.78 | |
| WBV (mm3) | |||||
| 1.5T | 1012130.62 ± 82690.04 | 1004735.46 ± 91137.70 | 999603.62 ± 100589.75 | 962156.12 ± 128555.77 | |
| 3.0T | 1055812.20 ± 96075.16 | 1045919.93 ± 104699.17 | 1055534.44 ± 105181.07 | 990730.29 ± 113365.74 | |
| EV (mm3) | |||||
| 1.5T | 3919.88 ± 683.23 | 3720.85 ± 604.37 | 3244.77 ± 737.32 | 2755.47 ± 700.64 | |
| 3.0T | 3981.96 ± 672.66 | 3853.18 ± 522.93 | 3510.52 ± 772.85 | 2827.69 ± 645.60 | |
| MTLV (mm3) | |||||
| 1.5T | 20140.57 ± 2226.68 | 19510.58 ± 2707.68 | 18626.18 ± 2813.34 | 16847.00 ± 3598.37 | |
| 3.0T | 20656.41 ± 2466.61 | 21021.75 ± 2546.80 | 19967.09 ± 2782.28 | 17602.71 ± 2869.59 | |
| Adjusted HV | |||||
| 1.5T | 0.0047 ± 0.0005 | 0.0048 ± 0.0005 | 0.0040 ± 0.0006 | 0.0038 ± 0.0006 | <0.001 |
| 3.0T | 0.0051 ± 0.0005 | 0.0050 ± 0.0006 | 0.0044 ± 0.0007 | 0.0039 ± 0.0006 | <0.001 |
| Adjusted WBV | |||||
| 1.5T | 0.65 ± 0.04 | 0.66 ± 0.04 | 0.64 ± 0.04 | 0.63 ± 0.04 | 0.001 |
| 3.0T | 0.70 ± 0.04 | 0.71 ± 0.04 | 0.69 ± 0.04 | 0.66 ± 0.04 | <0.001 |
| Adjusted EV | |||||
| 1.5T | 0.0025 ± 0.0005 | 0.0025 ± 0.0004 | 0.0021 ± 0.0005 | 0.0018 ± 0.0004 | <0.001 |
| 3.0T | 0.0026 ± 0.0004 | 0.0026 ± 0.0003 | 0.0023 ± 0.0005 | 0.0019 ± 0.0004 | <0.001 |
| Adjusted MTLV | |||||
| 1.5T | 0.0130 ± 0.0011 | 0.0129 ± 0.0013 | 0.0120 ± 0.0015 | 0.0109 ± 0.0015 | <0.001 |
| 3.0T | 0.0138 ± 0.0015 | 0.0142 ± 0.0014 | 0.0130 ± 0.0015 | 0.0117 ± 0.0014 | <0.001 |
Data complied to normal distribution were shown in mean ± SD, while data not complied to normal distribution were shown in median and interquartile. HV, hippocampal volume; EV, entorhinal volume; WBV, whole-brain volume; MTL, middle temporal lobe volume. Adjusted regional volume, regional volume/intracranial volume.