TABLE 3.
Correlations of baseline CSF p-tau, t-tau, Aβ42/Aβ40 ratio, sTREM2, PRGN, and brain volumes (segmented in 3.0 T MRI) with cognitive status (measured by ADAS13) in subjects with cognition impairment.
| P | Beta (SE) | R 2 | |
| CSF p-tau concentration | 0.1998 | 4.188e-02 (3.259e-02) | 0.49 |
| CSF Aβ42/Aβ40 ratio | 0.6906 | –8.09229 (20.30536) | 0.49 |
| CSF sTREM2 concentration | 0.6692 | 8.463e-05 (1.979e-04) | 0.4903 |
| CSF PRGN concentration | 0.3292 | 6.638e-05 (6.792e-05) | 0.4918 |
| CSF t-tau concentration | 0.00226 | 0.06351 (0.02415) | 0.512 |
| Adjusted HV | 0.001413 | –2.577e+03 (7.926e+02) | 0.6546 |
| Adjusted EV | 0.000865 | –3.0.115549e+03 (1.044e+03) | 0.6566 |
| Adjusted MTLV | 0.000292 | –1.200e+03 (3.238e+02) | 0.6611 |
| Adjusted WBV | 0.012101 | –34.04622 (13.40968) | 0.6457 |
The correlations CSF p-tau, t-tau, Aβ42/Aβ40 ratio, sTREM2, PRGN, and brain volume with cognitive status (measured by ADAS13) were analyzed using multivariate linear regression. Beta (SE) refers to standardized regression coefficient with standard error. R2 refers to coefficient of determination. HV, hippocampal volume; EV, entorhinal volume; WBV, whole-brain volume; MTL, middle temporal lobe volume.