TABLE 4.
Statistical analysis of linear mixed-effect regression for CSF Aβ42/Aβ40 and CSF p-tau concentration in amyloid positive (A+) groups alone or in combination.
| CSF Aβ42/Aβ40 | ADAS13 | P | Adjusted P | Beta (SE) | d | MMSE | P | Adjusted P | Beta (SE) | d |
| CN A– | 0.68 | 0.99 | –0.030 (0.072) | NA | 0.78 | 0.98 | 0.021 (0.076) | NA | ||
| CN A+ | 0.85 | 0.99 | –0.023 (0.122) | NA | NA* | NA | NA | NA | ||
| MCI A+ | 0.99 | 0.99 | 0.001 (0.064) | NA | 0.98 | 0.98 | –0.002 (0.080) | NA | ||
| AD A+ | 0.50 | 0.99 | 0.053 (0.077) | NA | NA* | NA | NA | NA | ||
| MCI+AD A+ | 0.76 | 0.99 | 0.016 (0.054) | NA | 0.28 | 0.84 | –0.078 (0.072) | NA | ||
| CSF p-tau | ADAS13 | P | Adjusted P | Beta (SE) | d | MMSE | P | Adjusted P | Beta (SE) | d |
| CN A– | 0.50 | 0.63 | 0.052 (0.075) | NA | 0.41 | 0.41 | –0.066 (0.080) | NA | ||
| CN A+ | 0.01 | 0.02 | 0.319 (0.119) | 0.84 | NA* | NA | NA | NA | ||
| MCI A+ | <0.001 | 0.001 | 0.220 (0.063) | 0.56 | <0.001 | <0.001 | –0.298 (0.079) | –0.63 | ||
| AD A+ | 0.77 | 0.77 | 0.022 (0.073) | NA | NA* | NA | NA | NA | ||
| MCI+AD A+ | <0.001 | 0.001 | 0.192 (0.052) | 0.53 | <0.001 | <0.001 | –0.248 (0.071) | –0.51 |
p refers to the significance of interaction effect of CSF Aβ42/Aβ40 ratio (or CSF p-tau concentration) × time. The p-values are adjusted using false discovery rate (FDR). Beta (SE) refers to standardized regression coefficient with standard error. Cohen’s d refers to effect size of interaction effect of CSF Aβ42/Aβ40 ratio (or CSF p-tau concentration) × time. In ADAS13, negative effect size d means higher concentration (or ratio) is correlated with slower ADAS13 score increase, whereas positive effect size d means higher concentration (or ratio) is correlated with faster ADAS 13 score increase. In MMSE, negative effect size d means higher concentration (or ratio) is correlated with faster MMSE score decrease.
*Means the model did not fit well.