TABLE 5.
Statistical analysis of linear mixed-effect regression for CSF sTREM2 and CSF progranulin concentration in amyloid positive (A+) groups alone or in combination.
| CSF sTREM2 | ADAS13 | P | Adjusted P | Beta (SE) | d | MMSE | P | Adjusted P | Beta (SE) | d |
| CN A- | 0.05 | 0.08 | –0.158 (0.080) | NA | 0.53 | 0.53 | 0.056 (0.088) | NA | ||
| CN A+ | 0.73 | 0.91 | –0.053 (0.150) | NA | NA* | NA | NA | NA | ||
| MCI A+ | <0.001 | <0.001 | –0.220 (0.058) | –0.60 | 0.003 | 0.005 | 0.223 (0.074) | 0.49 | ||
| AD A+ | 0.97 | 0.97 | –0.090 (0.076) | NA | NA* | NA | NA | NA | ||
| MCI+AD A+ | <0.001 | <0.001 | –0.197 (0.049) | –0.58 | 0.001 | 0.003 | 0.225 (0.068) | 0.49 | ||
| CSF PRGN | ADAS13 | P | Adjusted P | Beta (SE) | d | MMSE | P | Adjusted P | Beta (SE) | Cohen’s d |
| CN A- | 0.46 | 0.58 | –0.055 (0.075) | NA | 0.27 | 0.70 | –0.087 (0.078) | NA | ||
| CN A+ | 0.60 | 0.60 | 0.053 (0.100) | NA | NA* | NA | NA | NA | ||
| MCI A+ | 0.28 | 0.47 | 0.049 (0.045) | NA | 0.70 | 0.70 | –0.022 (0.056) | NA | ||
| AD A+ | 0.12 | 0.43 | 0.053 (0.085) | NA | NA* | NA | NA | NA | ||
| MCI+AD A+ | 0.17 | 0.43 | 0.056 (0.041) | NA | 0.58 | 0.70 | –0.031 (0.056) | NA |
p refers to the significance of interaction effect of CSF sTREM2 concentration (or CSF progranulin) × time. The p-values are adjusted using false discovery rate (FDR). Beta (SE) refers to standardized regression coefficient with standard error. Cohen’s d refers to effect size of interaction effect of CSF sTREM2 concentration (or CSF progranulin) × time. In ADAS13, negative effect size d means higher concentrations are correlated with slower ADAS13 score increase, whereas positive effect size d means higher baseline concentrations are correlated with faster ADAS13 score increase. In MMSE, positive effect size d means higher concentrations are correlated with slower MMSE score decrease.
*Means the model did not fit well.