TABLE 6.
Statistical analysis of linear mixed-effect regression for CSF t-tau concentration and specific brain region volumes (segmented in 3.0 T structural MRI) in amyloid positive (A+) groups alone or in combination.
| CSF t-tau | ADAS13 | P | Adjusted P | Beta (SE) | d | MMSE | P | Adjusted P | Beta (SE) | d |
| CN A– | 0.63 | 0.84 | 0.199 (0.409) | NA | NA* | NA | NA | NA | ||
| CN A+ | 0.12 | 0.60 | –0.816 (0.514) | NA | NA* | NA | NA | NA | ||
| MCI A+ | 0.71 | 0.84 | –0.106 (0.288) | NA | 0.84 | 0.84 | –0.074 (0.356) | NA | ||
| AD A+ | 0.61 | 0.84 | 0.166 (0.325) | NA | NA* | NA | NA | NA | ||
| MCI+AD A+ | 0.84 | 0.84 | 0.046 (0.235) | NA | 0.12 | 0.24 | –0.491 (0.312) | NA | ||
| Adjusted HV | ADAS13 | P | Adjusted P | Beta (SE) | d | MMSE | P | Adjusted P | Beta (SE) | d |
| CN A– | 0.89 | 0.89 | –0.012 (0.085) | NA | 0.10 | 0.10 | 0.195 (0.116) | NA | ||
| CN A+ | 0.58 | 0.73 | 0.083 (0.148) | NA | NA* | NA | NA | NA | ||
| MCI A+ | 0.02 | 0.04 | –0.160 (0.065) | –0.53 | 0.001 | 0.002 | 0.307 (0.091) | 0.70 | ||
| AD A+ | 0.17 | 0.28 | 0.148 (0.104) | NA | NA* | NA | NA | NA | ||
| MCI+AD A+ | 0.01 | 0.04 | –0.145 (0.057) | –0.52 | <0.001 | <0.001 | 0.366 (0.086) | 0.91 | ||
| Adjusted EV | ADAS13 | P | Adjusted P | Beta (SE) | d | MMSE | P | Adjusted P | Beta (SE) | d |
| CN A– | 0.67 | 0.81 | 0.034 (0.080) | NA | 0.04 | 0.04 | 0.232 (0.109) | NA | ||
| CN A+ | 0.81 | 0.81 | –0.152 (0.148) | NA | NA* | NA | NA | NA | ||
| MCI A+ | 0.008 | 0.02 | –0.199 (0.073) | –0.65 | 0.000231 | 0.000347 | 0.377 (0.097) | 0.89 | ||
| AD A+ | 0.51 | 0.81 | 0.069 (0.102) | NA | NA* | NA | NA | NA | ||
| MCI+AD A+ | 0.002 | 0.008 | –0.206 (0.063) | –0.73 | <0.001 | <0.001 | 0.411 (0.092) | 1.1 | ||
| Adjusted MTLV | ADAS13 | P | Adjusted P | Beta (SE) | d | MMSE | P | Adjusted P | Beta (SE) | d |
| CN A– | 0.49 | 0.6125 | –0.057 (0.082) | NA | 0.54 | 0.54 | 0.072 (0.117) | NA | ||
| CN A+ | 0.93 | 0.93 | –0.010 (0.121) | NA | NA* | NA | NA | NA | ||
| MCI A+ | 0.01 | 0.03 | –0.158 (0.062) | –0.54 | <0.001 | <0.001 | 0.321 (0.086) | 0.79 | ||
| AD A+ | 0.10 | 0.17 | –0.176 (0.102) | NA | NA* | NA | NA | NA | ||
| MCI+AD A+ | <0.001 | 0.002 | –0.205 (0.055) | –0.72 | <0.001 | <0.001 | 0.449 (0.081) | 1.1 | ||
| Adjusted WBV | ADAS13 | P | Adjusted P | Beta (SE) | d | MMSE | P | Adjusted P | Beta (SE) | d |
| CN A– | 0.77 | 0.87 | 0.026 (0.086) | NA | 0.21 | 0.21 | 0.153 (0.120) | NA | ||
| CN A+ | 0.78 | 0.87 | –0.041 (0.144) | NA | NA* | NA | NA | NA | ||
| MCI A+ | 0.008 | 0.02 | –0.188 (0.069) | –0.62 | <0.001 | <0.001 | 0.417 (0.092) | 1.0 | ||
| AD A+ | 0.87 | 0.87 | 0.016 (0.099) | NA | NA* | NA | NA | NA | ||
| MCI+AD A+ | <0.001 | 0.004 | –0.207 (0.059) | –0.72 | 0.005 | <0.001 | 0.499 (0.084) | 1.3 |
p refers to the significance of interaction effect of CSF t-tau concentration (or brain volumes) × time. The p-values are adjusted using false discovery rate (FDR). Beta (SE) refers to standardized regression coefficient with standard error. Cohen’s d refers to effect size of interaction effect of CSF t-tau concentration (or brain volumes) × time. In ADAS13, negative effect size d means higher volumes are correlated with slower ADAS13 score increase, whereas positive effect size d means higher baseline CSF t-tau concentration is correlated with faster ADAS 13 score increase. In MMSE, positive effect size d means higher volumes are correlated with slower MMSE score decrease.
*Means the model did not fit well.