Figure 4. Regional Differences in Patient vs Control Activity on 2 Language Mapping Tasks, Including Naming and Semantic Decision.

Results are shown separately for perilesional tissue (4–16 mm of lesion boundary; top) and for tissue distant from the lesion (>16 mm from lesion boundary; bottom). In the naming task, (A) no regions near the lesion exhibited increased activation, but decreased activation was evident in frontal, parietal, and occipital lobes. (B) Far from the lesion, the decreased occipital lobe activation persisted, and 1 frontal lobe parcel exhibited increased activation. In the semantic decision task, (C) perilesional superior frontal sulcus and lateral occipital cortex exhibited increased activation, but (D) this increased activation was also evident in tissue distant from the lesion along with increased activity in other regions. Blue parcels, controls > people with aphasia; red parcels, people with aphasia > controls; p < 0.05, Benjamini–Hochberg false discovery rate.