Table 2.
The DEPs lists betweenBPIV3-infected group and mock group
| No. | Protein name | Uniprot Accession no | GO annotation | P value | V/C | ||
|---|---|---|---|---|---|---|---|
| Biological process | Cell component | Molecular function | |||||
| 1 | Integrin beta | Q6PT99 | Single organismal cell–cell; adhesionresponse to stimulus | Plasma membrane region | Integrin binding; molecular transducer activity; receptor activity | 0.042 | 0.412 |
| 2 | Uncharacterized | E1BEW4 | Regulation of cellular component organization | Membrane |
protein kinase activity; purine nucleotide binding |
0.014 | 0.421 |
| 3 | OCRL protein | A7E337 | Cellular component assembly; regulation of metabolic process | Extracellular region part; cytoplasm | Phosphatase activity; GTPase binding; | 0.037 | 0.425 |
| 4 | DTYMK protein | A5PJV9 | Metabolic process; biosynthetic process; | Cytoplasm | Nucleotide kinase activity; | 0.034 | 0.497 |
| 5 | Myosin-7 | Q9BE39 | Biosynthetic process; metabolic process; |
Actin cytoskeleton; intracellular |
Binding | 0.032 | 0.409 |
| 6 | Uncharacterized protein | E1BF95 | Regulation of kinase activity;regulation of metabolic process | Intracellular | Purine nucleotide binding | 0.048 | 0.420 |
| 7 | Mesoderm induction early response protein 2 | A5PJX4 | Regulation of primary metabolic process; regulation of cellular biosynthetic process | Nucleus; cellular_component | Binding | 0.037 | 0.466 |
| 8 | Uncharacterized protein | E1BKT3 | Macromolecule localization; intracellular transport |
Plasma membrane region; Membrane- |
Integrin binding | 0.037 | 0.477 |
| 9 | Selenoprotein P | P49907 | Signal transduction; G-protein coupled receptor signaling pathway |
Plasma membrane region; Dendrite |
Signaling receptor activity; | 0.042 | 0.480 |
| 10 | ERGIC and golgi 2 | Q0IIJ1 | – | Intracellular organelle; membrane-bounded organelle | – | 0.044 | 0.483 |
| 11 | Uncharacterized protein | G5E5P7 | – |
Cytoskeleton; intracellular part |
– | 0.012 | 0.516 |
| 12 | N-acylglucosamine 2-epimerase | G3MZ53 | Small molecule metabolic process | – | Racemase and epimerase activity | 0.006 | 0.524 |
| 13 | Serine protease HTRA1 | F1N152 |
Regulation of metabolic process; Signal transduction |
Cytoplasm; extracellular matrix | Serine hydrolase activity; insulin-like growth factor binding | 0.002 | 0.527 |
| 14 | GTP-binding protein SAR1a | Q3T0D7 | Macromolecule localization; cellular component assembly | Endoplasmic reticulum; membrane-bounded vesicle | Small molecule binding; | 0.049 | 0.528 |
| 15 | Uncharacterized protein | F1MDD5 | Developmental process; cell differentiation | Extracellular organelle | Receptor binding | 0.007 | 0.529 |
| 16 | Clusterin | F1MWI1 | Cell death; cellular process | – | – | 0.002 | 0.533 |
| 17 | Rab5 GDP/GTP ex-change factor | O18973 |
Regulation of metabolic process; Regulation of transport |
Cytoplasm; Recycling endosome |
Regulation of metabolic process | 0.022 | 0.541 |
| 18 | Calcyphosin | Q0VCC0 | Metabolic process; regulation of cellular catabolic proces |
cellular_component; intracellular part |
Cation binding | 0.001 | 0.558 |
| 19 | Uncharacterized protein | F1MS35 | Cellular component assembly; positive regulation of metabolic process |
cytoplasmic vesicle; nucleus |
Cation binding; enzyme regulator activity | 0.010 | 0.560 |
| 20 | Tissue factor pathway inhibitor 2 | Q7YRQ8 | Regulation of metabolic process;circulatory system development | Membrane-bounded organelle; | Endopeptidase regulator activity | 0.000 | 0.563 |
| 21 | TATA box-binding protein-associated factor RNA polymerase I subunit D | Q32LB6 | Regulation of metabolic process | Membrane-bounded organelle | Nucleic acid binding | 0.031 | 0.566 |
| 22 | Uncharacterized protein | E1BDC9 |
Digestive tract development; cell differentiation |
Cytoplasm; end-omembrane system | binDing | 0.032 | 0.570 |
| 23 | Uncharacterized protein | F1N2K8 | Single-organism developmental process | Cytoplasmic part | Protein binding | 0.007 | 0.578 |
| 24 | Uncharacterized protein | F1MH50 | Regulation of cytoskeleton organization | Cytoplasm | Protein binding | 0.001 | 0.579 |
| 25 | Uncharacterized protein | G3N1L7 | Extracellular matrix | Ion binding | 0.004 | 0.582 | |
| 26 | MHC(BoLA) class II DR-beta chain | Q9TTM7 | Antigen processing and presentation | Extracellular matrix;cytoplasmic part | Binding | 0.033 | 0.582 |
| 27 | Transmembrane protein 106B | Q3ZC25 |
Developmental process; Cell morpho-genesis |
Membrane; Cytoplasm |
– | 0.002 | 0.582 |
| 28 | Uncharacterized protein | E1BM92 | Single-multicellular organism process |
Plasma membrane region; Cytoplasm |
Cytoskeletal protein binding | 0.041 | 0.588 |
| 29 | Mitochondrial ribonuclease P protein 1 | Q2KI45 | Nucleic acid metabolic process |
Intracellular organelle; Nucleoplasm |
Catalytic activity; Transferase activity |
0.033 | 0.594 |
| 30 | Periplakin | M5FKH8 | Developmental process; | Cytoskeleton; Intracellular part | Binding | 0.004 | 0.595 |
| 31 | Proteasome assembly chaperone 1 | Q0P5F2 |
Cellular component assembly; Organ development |
Cytoplasm; Intracellular organelle |
Proteasome binding | 0.035 | 0.597 |
| 32 | Uncharacterized protein | E1B8X6 | Transport; |
Intracellular; Lysosome |
– | 0.009 | 0.607 |
| 33 | Glutathione S-transferase | A5PJE0 | Metabolic process | intracellular part | Transferase activity | 0.016 | 0.607 |
| 34 | Receptor-type tyrosine-protein phosphatase F | A7MBJ4 | Regulation of response to stimulus; cell development | Membrane | Anion binding | 0.025 | 0.608 |
| 35 | Haloacid dehalogenase-like hydrolase domain-containing protein 3 | Q5E9D6 | Small molecule metabolic process | – | Hydrolase activity; phosphatase activity | 0.015 | 0.612 |
| 36 | Uncharacterized protein | F1MD78 | – | Intracellular organelle part; nuclear part | – | 0.015 | 0.614 |
| 37 | Alpha-1-antiproteinase | P34955 |
Regulation of metabolic process; Negative regulation of catalytic activity |
Endoplasmic reticulum; intracellular organelle | Glycoprotein binding; enzyme binding; enzyme inhibitor activity | 0.044 | 0.617 |
| 38 | NUP35 protein | A6QPZ3 | Transport | Membrane | – | 0.010 | 0.619 |
| 39 | Lysosomal alpha-glucosidase | Q9MYM4 | Metabolic process | Intracellular organelle; extracellular organelle | Hydrolase activity | 0.025 | 0.625 |
| 40 | Uncharacterized protein | F1MJB0 | – | – | – | 0.013 | 0.626 |
| 41 | Uncharacterized protein | E1BI31 | Positive regulation of immune system process | Intracellular organelle; membrane | Enzyme binding | 0.040 | 0.629 |
| 42 | Proteasome subunit alpha type-2 | Q3T0Y5 | Cellular protein metabolic process; multi-organism process | Extracellular vesicle; intracellular organelle | Endopeptidase activity | 0.031 | 0.631 |
| 43 | Uncharacterized protein | F1MNT4 | tissue development; regulation of cellular process | Extracellular matrix | Integrin binding | 0.002 | 1.502 |
| 44 | Up-regulator of cell proliferation | G3X839 | apoptotic process | – | – | 0.011 | 1.504 |
| 45 | Uncharacterized protein | F1MPD4 | – | – | – | 0.000 | 1.508 |
| 46 | Uncharacterized protein | G3MZ27 | Single-organism process | Membrane part | Trans-membrane signaling receptor activity | 0.003 | 1.511 |
| 47 | CD44 antigen | F1MHC3 | Cell adhesion | Integral component of membrane | Binding | 0.000 | 1.512 |
| 48 | Uncharacterized protein | G3X6B3 | Immune system process | Membrane | Nucleic acid binding | 0.041 | 1.515 |
| 49 | Leucine-rich repeat flightless-interacting protein 2 | E1BBW0 | – | Cytoplasm; membrane | Protein binding | 0.009 | 1.530 |
| 50 | Tyrosine-protein phosphatase non-receptor type | A6QQN2 | Apoptotic signaling pathway | Endoplasmic reticulum | Phosphatase activity | 0.006 | 1.537 |
| 51 | Uncharacterized protein | G5E6P8 | Lipid metabolic process | Membrane | Hydrolase activity | 0.016 | 1.537 |
| 52 | Mitogen-activated protein kinase 7 | A5PKJ4 | Intracellular transport | Cytoplasm | Kinase binding | 0.044 | 1.541 |
| 53 | 78 kDa glucose-regulated protein | Q0VCX2 | Regulation of cell migration | Cytoplasmic vesicle | Small molecule binding | 0.000 | 1.542 |
| 54 | NSL1 protein | A6QQ16 | Primary metabolic process | Intracellular organelle | Hydrolase activity | 0.037 | 1.544 |
| 55 | Tryptophan-tRNA ligase, cytoplasmic | P17248 | Metabolic process | Intracellular organelle | Binding | 0.000 | 1.544 |
| 56 | Uncharacterized protein | F1MWL1 | Cellular protein metabolic process | Actin cytoskeleton | Hydrolase activity | 0.000 | 1.545 |
| 57 | Uncharacterized protein | E1B7E1 | Regulation of developmental process | Intracellular organelle | Protein binding | 0.027 | 1.546 |
| 58 | Band 4.1-like protein 5 | Q58CU2 | Cytoplasm; membrane | Protein binding | 0.011 | 1.555 | |
| 59 | Myosin-1 | Q9BE40 | Metabolic process | Intracellular organelle | Binding | 0.027 | 1.558 |
| 60 | Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 1 | A6QL95 | Cellular biosynthetic process | Endoplasmic reticulum | Catalytic activity | 0.027 | 1.560 |
| 61 | DPYSL5 protein | A8E641 | Developmental process | Cytoplasm | Hydrolase activity | 0.000 | 1.560 |
| 62 | MOB kinase activator 3A | Q58D63 | Intracellular | cation binding | 0.001 | 1.561 | |
| 63 | Store-operated calcium entry-associated regulatory factor | Q08E24 | Regulation of transport | Intracellular organelle | – | 0.041 | 1.565 |
| 64 | Phosphoribosyl pyrophosphate synthase-associated protein 1 | Q08DW2 | Compound metabolic process | – | Transferase activity | 0.005 | 1.578 |
| 65 | Uncharacterized protein | F1MHH5 | Cell–cell adhesion | Membrance | Signaling receptor activity | 0.038 | 1.580 |
| 66 | Nuclear speckle-splicing regulatory protein 1 | F1MMV5 | Metabolic process | Nucleus | Binding | 0.002 | 1.583 |
| 67 | SF3B2 protein | A4FV01 | – | Intracellular | Nucleic acid binding | 0.027 | 1.585 |
| 68 | Guanine nucleotide-binding protein, beta-1 subunit | A7E3V7 | Cellular response to organic substance | Membrane part | Hydrolase activity | 0.004 | 1.604 |
| 69 | Transcription factor MafF | A7YY73 | Organ development | Intracellula | Nucleic acid binding | 0.001 | 1.610 |
| 70 | Sorting and assembly machinery component 50 homolog | G3MZZ3 | Protein complex biogenesis | Integral component of membrane | – | 0.001 | 1.611 |
| 71 | Low-density lipoprotein receptor | P01131 | Lipid metabolic process | Plasma membrane raft | – | 0.003 | 1.612 |
| 72 | MKK3 protein | A4IFH7 | Inflammatory response | Intracellular | Protein kinase activity | 0.002 | 1.619 |
| 73 | Fibroblast growth factor | A6QPP3 | Single-organism developmental process | Plasma membrane | Kinase regulator activity | 0.029 | 1.619 |
| 74 | Uncharacterized protein | E1BIU0 | Cellular protein localization | Membrane | Binding | 0.000 | 1.630 |
| 75 | Uncharacterized protein (Fragment) | E1BJL9 | Regulation of immune system process | Membrane | Cytokine receptor binding | 0.025 | 1.634 |
| 76 | AP-2 complex subunit beta | P63009 | Intracellular protein transport | Membrane | Transporter activity | 0.035 | 1.639 |
| 77 | Uncharacterized protein | F1MPF7 | Developmental process | Extracellular organelle | Binding | 0.001 | 1.653 |
| 78 | Scavenger receptor cysteine-rich type 1 protein M130 | P85521 | Inflammatory response | Membrane | Receptor activity | 0.000 | 1.658 |
| 79 | ALG2 protein | A4FUG6 | Protein metabolic process | Cytoplasmic part | Protein binding | 0.000 | 1.660 |
| 80 | Collagen alpha-2(XI) chain | F1MRP6 | Extracellular region | Ion binding | 0.001 | 1.668 | |
| 81 | Uncharacterized protein | E1BMF2 | Protein metabolic process | Extracellular region | Peptidase activity | 0.002 | 1.677 |
| 82 | Uncharacterized protein | F6R9F1 | Cellular response to stimulus | Intracellular | Binding | 0.000 | 1.679 |
| 83 | Radial spoke head protein 3 homolog | A8E4N3 | – | – | – | 0.031 | 1.680 |
| 84 | Cysteine and glycine-rich protein 2 | Q32LE9 | Developmental process | Intracellular | Ion binding | 0.005 | 1.683 |
| 85 | Arf-GAP domain and FG repeat-containing protein 1 | Q2TA45 | Developmental process | Membrane-bounded vesicle | Enzyme regulator activity | 0.035 | 1.686 |
| 86 | TACC3 protein | A6QL93 | Response to stimulus | Intracellular organelle | Binding | 0.000 | 1.687 |
| 87 | Myristoylated alanine-rich C-kinase substrate | P12624 | Cytoplasm | Protein binding | 0.006 | 1.697 | |
| 88 | ER lumen protein-retaining receptor 1 | P33946 | Regulation of transport | Cytoplasmic part | Peptide binding | 0.005 | 1.705 |
| 89 | Kelch-like protein 9 | F1MXI0 | Metabolic process | Intracellular part | Transferase activity | 0.033 | 1.713 |
| 90 | Wiskott-Aldrich syndrome protein family member 2 | A2VDK6 | Cell migration | Extracellular region part | Protein binding | 0.006 | 1.717 |
| 91 | Cytosolic carboxypeptidase 3 | G3N121 | Protein metabolic process | Cytoplasm | Binding | 0.034 | 1.717 |
| 92 | Uncharacterized protein | F1MQ43 | Regulation of metabolic process | Membrane | Enzyme binding | 0.000 | 1.737 |
| 93 | Collagen alpha-1(IV) chain | Q7SIB2 | Single-organism process | Extracellular region| | Protein binding | 0.002 | 1.763 |
| 94 | Uncharacterized protein | E1BG99 | Regulation of metabolic process | – | – | 0.000 | 1.852 |
| 95 | Uncharacterized protein | E1B9F3 | Cellular developmental process | Cytoplasm | Protein binding | 0.000 | 1.863 |
| 96 | Uncharacterized protein | E1B7H4 | Response to stress | Cytoplasm | Protein kinase activity | 0.002 | 1.885 |
| 97 | Protein phosphatase inhibitor 2 | F1MTZ0 | Regulation of signal transduction | Enzyme regulator activity | 0.000 | 1.891 | |
| 98 | Fibronectin type 3 and ankyrin repeat domains protein 1 | F1MCR5 | – | Intracellular | – | 0.000 | 1.901 |
| 99 | Calcium/calmodulin-dependent protein kinase I | Q08DQ1 | Biosynthetic process | Intracellular | Nucleoside binding | 0.001 | 1.927 |
| 100 | Nucleoredoxin | A6QLU8 | Regulation of protein metabolic process | Cytoplasm | Antioxidant activity | 0.004 | 1.949 |
| 101 | Uncharacterized protein | F1MX40 | Metabolic process | Nucleoside binding | Nucleotide binding | 0.000 | 1.959 |
| 102 | CA(2+)-dependent carbohydrate-binding protein | Q9TRL9 | Regulation of developmental process | Nucleus | Binding | 0.004 | 1.962 |
| 103 | Uncharacterized protein | F1MJZ0 | Regulation of system process | Membrane | Signaling receptor activity | 0.001 | 1.970 |
| 104 | PDZ and LIM domain protein 2 | Q3T0C8 | Cell junction | Cation binding | 0.002 | 1.979 | |
| 105 | Uncharacterized protein | E1B7M1 | Cellular developmental process | – | Exchange factor activity | 0.022 | 1.998 |
| 106 | Uncharacterized protein | F1MQI1 | Cellular protein localization | Intracellular organelle | Receptor binding | 0.021 | 2.085 |
| 107 | Uncharacterized protein | F1MWF0 | Regulation of protein metabolic process | Cytoplasmic vesicle | phospholipid binding | 0.007 | 2.243 |
| 108 | NCK adaptor protein 1 | Q1LZB2 | Regulation of signaling | Cell–cell junction | Protein kinase inhibitor activity | 0.001 | 2.252 |
| 109 | Sjoegren syndrome nuclear autoantigen 1 homolog | G3MWY9 | Regulation of cellular process | Cytoplasm | Protein binding | 0.000 | 2.254 |
| 110 | Uncharacterized protein | E1BGM1 | – | – | Ion binding | 0.001 | 2.294 |
| 111 | Pescadillo homolog | E1BM72 | Primary metabolic process | Nucleus; membrane | Nucleic acid binding | 0.028 | 2.434 |
| 112 | Transcription elongation factor SPT5 | A7YW40 | Metabolic process | Nucleus; intracellular | Binding | 0.000 | 2.604 |
| 113 | Uncharacterized protein | F1MHA1 | Biological regulation | Intracellular part | Transferase activity | 0.000 | 3.021 |
| 114 | Uncharacterized protein | F1MSV7 | Regulation of secretion | Intracellular | Metal ion binding | 0.008 | 3.075 |
| 115 | Vesicle-associated membrane protein 3 | G3X752 | Regulation of secretion | cytoplasm | Binding | 0.000 | 3.850 |
| 116 | Uncharacterized protein | F1MJN7 | – | – | Binding | 0.0000 | |
V/C virus/control