Table 2.
Performances of biomarkers for the diagnosis of BCa
| AUC (95% CI) | Cut-off value | Sensitivity (%) | Specificity (%) | |
|---|---|---|---|---|
| Healthy vs. All BCa | ||||
| POSTN | 0.78 (0.72 – 0.83)a1 | 14.5 | 71.7 | 75.4 |
| CA153 | 0.68 (0.61 – 0.74) | 16.7 | 45.7 | 89.9 |
| CEA | 0.68 (0.61 – 0.74) | 2.2 | 49.1 | 84.0 |
| POSTN + CA153 | 0.80 (0.75 – 0.85)c3 | - | 76.3 | 72.5 |
| POSTN + CEA | 0.82 (0.77 – 0.87)c3 | - | 74.0 | 78.3 |
| POSTN + CA153 + CEA | 0.83 (0.78 – 0.87)c3 | - | 70.5 | 81.1 |
| Healthy vs. locoregional BCa | ||||
| POSTN | 0.72 (0.65 – 0.79)b | 14.2 | 65.2 | 73.9 |
| CA153 | 0.57 (0.49 – 0.64) | 14.3 | 37.4 | 82.6 |
| CEA | 0.62 (0.55 – 0.69) | 2.1 | 46.1 | 79.7 |
| POSTN + CA153 | 0.74 (0.67 – 0.80)c1 | - | 68.7 | 71.0 |
| POSTN + CEA | 0.77 (0.70 – 0.82)c3 | - | 86.1 | 59.4 |
| POSTN + CA153 + CEA | 0.77 (0.70 – 0.83)c3 | - | 87.8 | 55.1 |
| Locoregional BCa vs. distant BCa | ||||
| POSTN | 0.78 (0.71 – 0.84) | 25.8 | 67.2 | 79.1 |
| CA153 | 0.82 (0.76 – 0.88) | 19.3 | 75.9 | 74.8 |
| CEA | 0.68 (0.61 – 0.75) | 2.6 | 63.8 | 70.4 |
| POSTN + CA153 | 0.84 (0.78 – 0.89) 3 | - | 84.5 | 71.3 |
| POSTN + CEA | 0.81 (0.74 – 0.86) | - | 58.6 | 92.1 |
| POSTN + CA153 + CEA | 0.85 (0.78 – 0.90) 3 | - | 74.1 | 83.5 |
a−c, in comparison with CA153: a, P < 0.05; b, P < 0.01; c, P < 0.001
1–3, in comparison with CEA: 1, P < 0.05; 2, P < 0.01; 3, P < 0.001