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. 2022 Jul 14;20:323. doi: 10.1186/s12951-022-01536-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — ZnCM NPs attenuated RA progression in vivo by targeting splenic DCs. a The bio-distribution pattern in vivo of ZnC, ZnCM NPs in disparate organs based on Zn²⁺ concentrations. b IVIS imaging of RA mice injected with ZnC, ZnCM NPs retrobular (H: Heart, Li: Liver, S: Spleen, Lu: Lung, K: Kidney). c In vivo Bio-TEM investigations of splenic DCs in RA mice treated with ZnC, ZnCM NPs. The red arrow indicated the in vivo localization of NPs in splenic DCs. d Alleviation of ankle swelling after NPs treatments in RA mice. e Quantitative measurements of swelling paw perimeters weekly. f Pressure–time diagram showed the time course within single stance highlighted by different colors for each limb in RA mice injected with NPs from visual gait analysis system. g Quantitative results of hind limb pressure in RA mice injected with NPs. h Quantitative results of hind-base width in RA mice injected with NPs. i Quantitative results of mean rotate angle in RA mice injected with NPs. LF: left front limb, RF: right front limb; LH: left hind limb, RH: right hind limb. ** indicated the significant difference of p ≤ 0.05 compared with Vehicle, # indicated the significant difference of p ≤ 0.05 compared with Ctrl