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. 2022 Jul 14;159:29. doi: 10.1186/s41065-022-00241-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Expression, GO and KEGG analysis of DE-miRNAs in arecoline-induced cancer. A Volcanic plot of the GSE45238 data comparing patients with arecoline-induced cancer and healthy controls. Significantly upregulated miRNAs are indicated with red dotes, while downregulated miRNAs are indicated with green dotes. The dashed line illustrates the cut-off for significance (p < 0.01; T-test). B Circular cluster map. Upregulated miRNAs are indicated with red dotes, while downregulated miRNAs are indicated with green dotes. C Heat map of the top 15 up- or downregulated miRNAs. Red markers upregulation; blue, downregulation. D Enrichment of DE-miRNAs in GO biological processes (BPs). E Enrichment of DE-miRNAs in GO molecular functions (MFs). F Enrichment of DE-miRNAs in GO cellular components (CCs). G KEGG pathway enrichment analysis of DE-miRNAs. Node color and size reflect the log₁₀ (p value) and count, respectively