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. 2022 Jul 14;14:87. doi: 10.1186/s13148-022-01310-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Manhattan plot and Q–Q plot of the association between FSI and salivary DNA methylation. Manhattan plots of salivary DNA methylation associated with FSI (Fetal Stress Index). The x-axis represents the genomic loci of the individual CpGs and the y-axis represents the –log10 (p value). Black line: Bonferroni threshold (p = 6.183879e-08) and the dotted line: Multiple testing correction threshold (FDR < 0.05) has been added to the plot. CpGs that cross the FDR threshold are marked in the Manhattan plot. There are no DMPs that cross the Bonferroni correction threshold. Quantile–quantile (Q–Q) plot shows the expected and the observed quantiles and has a lambda 1.01