Table 2.

CpG sites associated with stress measures in DNA methylation analysis

Stress measure	Probe	Coefd	P.Valuee	FDRf	chrg	Illumina gene annotation	Genes within 50 kb of associated CpG
PSSa	cg17478679	−0.2	3.59E-07	0.25	chr17	KPNB1	CRHR1
	cg22124215	−0.1	1.07E-06	0.25	Chr2	MARCH4	DIRC3
	cg06195987	0.52	1.96E-06	0.25	Chr7	NA	LMTK2
	cg15426815	0.31	2.24E-06	0.25	Chr12	MIR200C	C1S
PDQb	cg06542869	0.02	4.62E-08	0.03	chr11	YAP1	YAP1
	cg22861369	0.02	2.30E-07	0.08	chr5	PDLIM4	SLC22A4
	cg01629131	0.03	3.31E-07	0.08	chr20	NA	RP11, RP1
	cg03105159	0.01	7.18E-07	0.11	chr2	ALKAL2	ALKAL2, FAM105B
Cortisol	cg11409463	0.003	2.87E-09	0.002	chr5	NA	SCAMP1
	cg20905655	0.004	1.16E-07	0.03	chr19	NA	SSBP4;
	cg25252839	0.002	1.24E-07	0.03	chr1	TOMM20	SNORA14B
	cg05306225	−0.002	2.08E-07	0.04	chr8	CSMD1	CSMD1
FSIc	cg13547817	−0.39	8.85E-08	0.07	chr9	ERP44	ERP44; INVS
	cg07642729	−0.35	2.81E-06	0.49	chr8	ASB15	-
	cg24795351	−0.34	3.79E-06	0.49	chr8	PREX2	PREX2
	cg16692227	−0.21	3.80E-06	0.49	chr14	SAMD12	SAMD12

The table shows top four CpGs from the EWAS that are associated with the respective stress measures. Marked in bold are significant

^aCohen Perceived Stress Scale

^bPrenatal Distress Questionnaire

^cFetal Stress Index

^dRegression coefficients from the statistical model

^eSignificance from the statistical model

^fFalse discovery rate

^gChromosome

NA: Not available